Phosphorylation of Betti Base with Bis(diethylamino)phosphoryl Chloride

摘要

The reaction of bis(diethylamino)phosphoryl chloride with N-Boc-protected 1-(-aminobenzyl)-2- naphthol (Betti base) proceeded via O-phosphorylation of the phenolic OH group to form the target product as trifluoroacetate salt. The latter reacted with O,O-diethyl thiophosphorylisothiocyanate to give thiourea bearing a chiral Betti base fragment.