Synthesis and Antitumor Evaluation of Novel Alkylated Hydantoin and Thiohydantoin Derivatives

Ahmed A. H.; Ebead A.; Afifi H.; Abdel-Rahman A. A. -H.

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Synthesis and Antitumor Evaluation of Novel Alkylated Hydantoin and Thiohydantoin Derivatives

机译：新型烷基化含苯酚和硫代脱蛋白衍生物的合成与抗肿瘤评价

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摘要

New alkylated hydantoin as well as 2-thiohydantoins were synthesized for broadening the library of compounds screened for antitumor activity. Antitumor activity of the new compounds was evaluated against breast cancer cell line (MCF-7) and demonstrated moderate to good activity.

机译：合成了新的烷基化乙酰脲以及2-硫代硫酸盐，用于拓宽筛选抗肿瘤活性的化合物文库。评估抗乳腺癌细胞系（MCF-7）的新化合物的抗肿瘤活性，并表现出中度至良好的活性。

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来源
《Russian Journal of General Chemistry》 |2019年第2期|共7页
作者
Ahmed A. H.; Ebead A.; Afifi H.; Abdel-Rahman A. A. -H.;
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作者单位

Univ Sci &

Tecnol Dept Chem Fac Med Sci Taeez Yemen;

Arish Univ Dept Chem Fac Sci Cairo Egypt;

Beni Suef Univ Fac Ind Educ Bani Suwayf Egypt;

Menoufia Univ Fac Sci Dept Chem Shibin Al Kawm 32511 Egypt;

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原文格式 PDF
正文语种 eng
中图分类化学;
关键词
hydantoin; 2-thiohydantoin; 1; 2; 3-benzotriazole; antitumor activity;

机译：杜娟素;2-硫代氢胺;1;2;3-苯并三唑;抗肿瘤活动;

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1. Synthesis and Antitumor Evaluation of Novel Alkylated Hydantoin and Thiohydantoin Derivatives [J] . Ahmed A. H., Ebead A., Afifi H., Russian Journal of General Chemistry . 2019,第2期

机译：新型烷基化含苯酚和硫代脱蛋白衍生物的合成与抗肿瘤评价
2. Synthesis, Molecular Modeling, and Biological Evaluation of Novel Tetrahydro-β-Carboline Hydantoin and Tetrahydro-β-Carboline Thiohydantoin Derivatives as Phosphodiesterase 5 Inhibitors [J] . Abadi Ashraf H., Lehmann Jochen, Piazza Gary A., International journal of medicinal chemistry. . 2011,第1期

机译：新型四氢-β-Carboline乙内酰脲和四氢-β-Carboline硫代乙内酰脲衍生物作为磷酸二酯酶5抑制剂的合成，分子建模和生物学评估
3. Synthesis, Molecular Modeling, and Biological Evaluation of Novel Tetrahydro-β-Carboline Hydantoin and Tetrahydro-β-Carboline Thiohydantoin Derivatives as Phosphodiesterase 5 Inhibitors [J] . Abadi Ashraf H., Lehmann Jochen, Piazza Gary A., International journal of medicinal chemistry. . 2011,第1期

机译：新型四氢-β-Carboline乙内酰脲和四氢-β-Carboline硫代乙内酰脲衍生物作为磷酸二酯酶5抑制剂的合成，分子建模和生物学评估
4. Synthesis and biological evaluation of the novel antitumor agent 3'-monosubstituted chalcone derivatives [C] . Luyao Wang, Hongye Zhao, Dan Wu, International Conference on Material, Mechanical and Manufacturing Engineering . 2015

机译：新型抗肿瘤剂的合成与生物学评价3'-单取代的硫酮衍生物
5. Poly(alpha,L-glutamic acid): Synthesis of its monodisperse derivatives and interaction of its alkylated derivatives with phospholipid bilayer membranes. [D] . Zhang, Guanghui. 1994

机译：聚（α，L-谷氨酸）：其单分散衍生物的合成及其烷基化衍生物与磷脂双层膜的相互作用。
6. Synthesis Molecular Modeling and Biological Evaluation of Novel Tetrahydro-β-Carboline Hydantoin and Tetrahydro-β-Carboline Thiohydantoin Derivatives as Phosphodiesterase 5 Inhibitors [O] . Ashraf H. Abadi, Jochen Lehmann, Gary A. Piazza, 2011

机译：新型四氢-β-Carboline乙内酰脲和四氢-β-Carboline硫代乙内酰脲衍生物作为磷酸二酯酶5抑制剂的合成分子建模和生物学评估
7. Synthesis, Molecular Modeling, and Biological Evaluation of Novel Tetrahydro-β-Carboline Hydantoin and Tetrahydro-β-Carboline Thiohydantoin Derivatives as Phosphodiesterase 5 Inhibitors [O] . Ashraf H. Abadi, Jochen Lehmann, Gary A. Piazza, 2011

机译：新型四氢-β-碳溶液乙素和四氢-β-碳甲醇硫胺衍生物作为磷酸二酯酶5抑制剂的合成，分子建模和生物学评价

Synthesis and Antitumor Evaluation of Novel Alkylated Hydantoin and Thiohydantoin Derivatives

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