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首页> 外文期刊>Age. >Effects of aging and menopause on serum interleukin-6 levels and peripheral blood mononuclear cell cytokine production in healthy nonobese women
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Effects of aging and menopause on serum interleukin-6 levels and peripheral blood mononuclear cell cytokine production in healthy nonobese women

机译:衰老和更年期对健康非肥胖女性血清白细胞介素6水平和外周血单个核细胞细胞因子产生的影响

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Inappropriate interleukin-6 production is thought to play a role in the development of several age-related conditions including atherosclerosis. This study aimed to determine whether aging affects circulating interleukin-6 (IL-6) levels. Healthy, nonobese women (n=208, 44.5±0.70 years, 22.4±0.17 kg/m 2) were categorized into four age groups (22-31, 32-41, 42-51, and 52-63 years; cross-sectional study). Cytokine levels in serum and those produced from peripheral blood mononuclear cell (PBMC) were measured. The oldest group had the highest circulating levels of IL-6 and oxidized low-density lipoprotein (ox-LDL) and higher PBMC production of IL-6, tumor necrosis factor-α (TNF-α), and interleukin-1 alpha (IL-1β). Additionally, significant interactions between age and menopause were found for serum IL-6 (P=0.024), and TNF-α (P=0.011) and IL-1β (P0.001) produced from PBMCs. Serum IL-6 levels positively correlated with age, waist-hip ratio (WHR), systolic blood pressure, circulating levels of TNF-α, IL-1β, and ox-LDL, and urinary 8-epi-prostaglandin F 2α. Multiple stepwise regression models identified the following factors for contributing to serum IL-6 levels: serum IL-1β, menopause status, WHR, and serum TNF-α in mode I (R 2=0.302); serum IL-1β, age, serum TNF-α, and WHR (β=0.197; P=0.006) in model II (R 2=0.283). Sub-analysis was performed according to menopausal status. Serum IL-6 levels were positively associated with levels of IL-6, TNF-α, and IL-1β in PBMC supernatants (unstimulated) from postmenopausal women, whereas these were negatively associated in premenopausal women. In conclusion, circulating IL-6 levels may be interactively influenced by age and menopause. Additionally, estrogen deprivation after menopause may enhance PBMC cytokine production in postmenopausal women, resulting in increased IL-6 levels which are closely related to oxidative stress.
机译:白细胞介素6的生产不当被认为在包括动脉粥样硬化在内的几种与年龄有关的疾病的发展中起作用。这项研究旨在确定衰老是否会影响循环中的白介素6(IL-6)水平。健康的非肥胖女性(n = 208、44.5±0.70岁,22.4±0.17 kg / m 2)分为四个年龄段(22-31岁,32-41、42-51和52-63岁);横断面研究)。测量血清和外周血单个核细胞(PBMC)产生的细胞因子水平。年龄最大的组的IL-6和氧化型低密度脂蛋白(ox-LDL)的循环水平最高,IL-6,肿瘤坏死因子-α(TNF-α)和白介素-1α(IL -1β)。此外,发现PBMCs产生的血清IL-6(P = 0.024),TNF-α(P = 0.011)和IL-1β(P <0.001)在年龄和更年期之间存在显着的相互作用。血清IL-6水平与年龄,腰臀比(WHR),收缩压,TNF-α,IL-1β和ox-LDL的循环水平以及尿中的8-前列腺素F2α呈正相关。多个逐步回归模型确定了影响血清IL-6水平的以下因素:I模式下的血清IL-1β,更年期状态,WHR和血清TNF-α(R 2 = 0.302)。模型II(R 2 = 0.283)中的血清IL-1β,年龄,血清TNF-α和WHR(β= 0.197; P = 0.006)。根据更年期状态进行亚分析。绝经后妇女的PBMC上清液(未刺激)中血清IL-6水平与IL-6,TNF-α和IL-1β呈正相关,而绝经前妇女则与这些水平呈负相关。总之,循环的IL-6水平可能受年龄和更年期的影响。另外,绝经后雌激素的缺乏可能会增强绝经后妇女的PBMC细胞因子的产生,导致IL-6水平升高,这与氧化应激密切相关。

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