Syntheses of polyfunctional aromatic compounds from non-aromatic precursors

摘要

Syntheses of polyfunctional benzene derivatives from both cyclic and acyclic non-aromatic precursors are reviewed. Such aromatizations include transformations that use Diels - Alder reactions, transition metal-catalyzed reactions, base mediated aldol or Michael addition reactions or electrocyclic and pericyclic reactions. This review is limited to research that has been published since the last reviews in 2006, 2008, 2015 and 2018 and is specifically focused on aromatic and heteroaromatic compounds synthesized by construction of the benzene ring. It excludes heterocyclic compounds that lack a monocyclic benzene core. Applications of such aromatization reactions for the total syntheses of natural products as well as potential medicinal chemical entities are included.