Preparation and biological evaluation of 99mTc N-histamine as a model for brain imaging: in silico study and preclinical evaluation

摘要

In the present work, [99mTc]N-histamine has been labeled using [99mTc≡N]2+ core. Factors such as, amount of substrate, pH, reaction temperature, in vitro stability and reaction time, have been systematically studied to optimize high radiochemical purity (>99±0.3). Biodistribution studies indicate the suitability of [99mTc]N-histamine as a novel tracer to image brain. The complex of [99mTc]N-histamine may be considered a highly selective radiotracer for brain imaging.