Synthesis, Characterization, and Radiolabeling of Heterocyclic Bisphosphonate Derivative as a Potential Agent for Bone Imaging

摘要

1-Hydroxy-2-(2-pyridyl)ethanedisphosphonic acid monosodium salt (HPEDP) was prepared and labeled with_(99 m )Tc using two different reducing agents: SnCl~(2)·2H~(2)O and NaBH~(4); NaBH~(4)gave better results. The radiochemical purity of_(99 m )Tc(NaBH~(4))-HPEDP was 96 ± 4%, and the complex was stable in vitro for 6 h. The in vivo biodistribution studies performed in mice show highly selective uptake of the labeled compound in the skeletal system and rapid elimination via the urinary pathway. The maximum bone uptake was 32.3 ± 2.1% ID/organ.