Hyperhomocysteinemia in polycystic ovary syndrome: decreased betaine-homocysteine methyltransferase and cystathionine β-synthase-mediated homocysteine metabolism

Da Li; Hong-Xiang Liu; Yuan-Yuan Fang; Jia-Ning Huo; Qi-Jun Wu; Tian-Ren Wang; Yi-Ming Zhou; Xiu-Xia Wang; Xiao-Xin Ma

首页> 外文期刊>Reproductive biomedicine online >Hyperhomocysteinemia in polycystic ovary syndrome: decreased betaine-homocysteine methyltransferase and cystathionine β-synthase-mediated homocysteine metabolism

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Hyperhomocysteinemia in polycystic ovary syndrome: decreased betaine-homocysteine methyltransferase and cystathionine β-synthase-mediated homocysteine metabolism

机译：多囊卵巢综合征中的高纤维素血症：降低甜菜碱 - 同型甲基转移酶和胱硫脲β-合成酶介导的同型蛋白代谢

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机译：<！[CDATA [研究质疑是多囊卵巢综合征（PCOS）中的同囊内半胱氨酸的代谢特征吗？在来自非肥胖和肥胖对照受试者和PCOS患者的血清样品中测定Designhomocysteine浓度。研究了使用脱氢贫康酮（DHEA）或DHEA建立的PCOS大鼠模型中的同型半胱氨酸代谢组合与高脂饮食（HFD）组合。结果表明，PCOS患者的血清同型半胱氨酸浓度高于肥胖基团的对照组（P <0.05），肥胖群体中的血清同型素浓度明显高于非肥胖组，无论PCOS如何状态（Bothp <0.05）; （ii）与对照组相比，DHEA + HFD诱导的大鼠血清同型半胱氨酸浓度显着增加（P <0.05）; （iii）与对照组进行比较时，在DHEA + HFD诱导的大鼠的肝组织中，同型半胱氨酸代谢酶的mRNA浓度显着降低（均为P <0.0001）; （iv）与对照组相比，DHEA + HFD组中的甲基化浓度（P <0.05）和波（P <0.05和P <0.0001）启动子存在显着降低。将甲基化模式与先前的数据一起表明HhmtandcBSMight的黄甲基化启动子介导的转录活化是针对PCOS相关的HyperhomocysteInemia的防御机制。结论STHESE的结果表明，降低的Liverbhmtandcbs介导的同型半胱氨酸代谢可能在PCOS中的Hyperhomysteinemia中具有作用，并提供进一步的证据，以便在PCOS中降低肝功能的潜在作用。

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来源
《Reproductive biomedicine online》 |2018年第2期|共8页
作者
Da Li; Hong-Xiang Liu; Yuan-Yuan Fang; Jia-Ning Huo; Qi-Jun Wu; Tian-Ren Wang; Yi-Ming Zhou; Xiu-Xia Wang; Xiao-Xin Ma;
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作者单位

Centre of Reproductive Medicine ShengJing Hospital of China Medical University;

Department of Obstetrics and Gynecology ShengJing Hospital of China Medical University;

Centre of Reproductive Medicine ShengJing Hospital of China Medical University;

Department of Obstetrics and Gynecology ShengJing Hospital of China Medical University;

Department of Clinical Epidemiology ShengJing Hospital of China Medical University;

Department of Obstetrics Gynecology and Reproductive Sciences Yale School of Medicine;

Department of Medicine Brigham and Women's Hospital Harvard Institutes of Medicine Harvard;

Centre of Reproductive Medicine ShengJing Hospital of China Medical University;

Department of Obstetrics and Gynecology ShengJing Hospital of China Medical University;

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正文语种 eng
中图分类人体生理学;
关键词
Bhmt; Cbs; Homocysteine; Metabolism; Mtr; Polycystic ovary syndrome;

机译：BHMT;CBS;同性恋;新陈代谢;地铁;多囊卵巢综合征;

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1. Hyperhomocysteinemia in polycystic ovary syndrome: decreased betaine-homocysteine methyltransferase and cystathionine β-synthase-mediated homocysteine metabolism [J] . Da Li, Hong-Xiang Liu, Yuan-Yuan Fang, Reproductive biomedicine online . 2018,第2期

机译：多囊卵巢综合征中的高纤维素血症：降低甜菜碱 - 同型甲基转移酶和胱硫脲β-合成酶介导的同型蛋白代谢
2. Inhibition of betaine-homocysteine S-methyltransferase in rats causes hyperhomocysteinemia and reduces liver cystathionine beta-synthase activity and methylation capacity. [J] . Strakova J. Gupta S. Kruger W. D. Dilger R. N. Tryon K. Li L. Garrow T. A. Nutrition Research . 2011,第7期

机译：甜菜碱-高半胱氨酸 S -甲基转移酶的抑制导致高同型半胱氨酸血症，并降低肝胱硫醚β合酶的活性和甲基化能力。
3. Homocysteine metabolism in polycystic ovary syndrome [J] . GrodnitskayaE.E., KurtserM.A. Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology . 2012,第3期

机译：同型半胱氨酸在多囊卵巢综合征中的代谢
4. Inhibition of HIF-1 a Signaling in the Ovaries of Sprague-Dawley Rats with Polycystic Ovary Syndrome [C] . Fan Wang, Yanqing Wu, Kaizhuan Xiao International Conference on Applied Sciences, Engineering and Technology . 2014

机译：具有多囊卵巢综合征的Sprague-Dawley大鼠卵巢中HIF-1的抑制HIF-1的信号传导
5. Validation of the obese Ossabaw miniature pig as a model of the obese polycystic ovary syndrome phenotype with concomitant metabolic syndrome: Exploration of polycystic ovary syndrome pathophysiology using in vivo and in vitro models [D] . Newell-Fugate, Anne Elizabeth 2012

机译：肥胖的Ossabaw小型猪作为肥胖多囊卵巢综合征表型伴有代谢综合征的模型的验证：利用体内和体外模型探索多囊卵巢综合征的病理生理学
6. Inhibition of betaine-homocysteine S-methyltransferase in rats causes hyperhomocysteinemia and reduces liver cystathionine β-synthase activity and methylation capacity [O] . Jana Strakova, Sapna Gupta, Warren D Kruger, -1

机译：大鼠中甜菜碱 - 同型半胱氨酸S-甲基转移酶的抑制引起高胱氨酸血症并降低肝脏胱硫脲β-合酶活性和甲基化能力
7. IMPORTANT RISK FACTOR OF HYPERHOMOCYSTEINEMIA IN CARDIOVASCULAR SYSTEM DISEASES AND STATUS OF THE HOMOCYSTEINE LEVELS IN POLYCYSTIC OVARY SYNDROME [O] . Burcu İMRE, Duygu İMRE YETKİN, Cavidan GÜLERMAN 2021

机译：多囊卵巢综合征中的心血管系统疾病中高管抑制因素的重要风险因素及其同囊卵巢综合征

Hyperhomocysteinemia in polycystic ovary syndrome: decreased betaine-homocysteine methyltransferase and cystathionine β-synthase-mediated homocysteine metabolism

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