> Hypolipidemic and Hypocholesterolemic Effect of Elephantopus scaber in Streptozotocin Diabetic Rats

摘要

diabetic rats . Elephantopus scaber methanol, hexane and acetone extracts (150 mg kg -1 b.wt.) were administered orally for 60 days to streptozotocin (STZ) (60 mg kg -1 b.wt.) induced male diabetic > wistar rats . Humulin and glibenclamide were also administered for 60 days to streptozotocin (STZ) (60 mg kg -1 b.wt.) induced male diabetic > wistar rats . On the 61st day, the animals were sacrificed and the blood collected was tested for cholesterol, LDL, HDL and VLDL, respectively. Results: Data was analyzed using analysis of variance and student's t-test and a level of p<0.05 was considered statistically significant. Administration of the different extracts of E. scaber brought about a significant reduction in serum cholesterol, LDL, VLDL and triglycerides and increase in the HDL-cholesterol in > diabetic rats . Conclusion: Hence, this study proves the protective and restorative effect of E. scaber in reverting the lipid alterations and complications of diabetes. Due to such attributes, E. scaber can be a source of potent drug to mitigate the complications of diabetes.]]>