Efficacy of elbasvir and grazoprevir in participants with hepatitis C virus genotype 4 infection: A pooled analysis

Asselah Tarik; Reesink Hendrik; Gerstoft Jan; de Ledinghen Victor; Pockros Paul J.; Robertson Michael; Hwang Peggy; Asante-Appiah Ernest; Wahl Janice; Nguyen Bach-Yen; Barr Eliav; Talwani Rohit; Serfaty Lawrence

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Efficacy of elbasvir and grazoprevir in participants with hepatitis C virus genotype 4 infection: A pooled analysis

机译：Elbasvir和Grazoprevir在丙型肝炎病毒基因型4感染的参与者中的疗效：汇总分析

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Background & Aims: The aim of this integrated analysis was to assess the efficacy of the once-daily combination of elbasvir 50 mg and grazoprevir 100 mg, with and without ribavirin in HCV genotype 4 (GT4)-infected participants enrolled in the Phase 2/3 clinical programme with elbasvir/grazoprevir.

机译：背景和目标：该综合分析的目的是评估Elbasvir 50mg和Grazoprevir 100mg的曾经每日组合的疗效，在HCV基因型4（GT4）中的利巴韦林，在阶段2 / 3临床计划用elbasvir / grazoprevir。

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《Liver international :》 |2018年第9期|共9页
作者
Asselah Tarik; Reesink Hendrik; Gerstoft Jan; de Ledinghen Victor; Pockros Paul J.; Robertson Michael; Hwang Peggy; Asante-Appiah Ernest; Wahl Janice; Nguyen Bach-Yen; Barr Eliav; Talwani Rohit; Serfaty Lawrence;
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作者单位

Univ Paris Diderot Beaujon Hosp AP HP INSERM UMR1149 Hepatol Dept Clichy France;

Univ Amsterdam Acad Med Ctr Amsterdam Netherlands;

Univ Copenhagen Dept Clin Med Copenhagen Denmark;

CHU Bordeaux Hop Haut Leveque Serv Hepatogastroenterol Pessac France;

Scripps Clin La Jolla CA USA;

Merck &

Co Inc Kenilworth NJ USA;

Merck &

Co Inc Kenilworth NJ USA;

Merck &

Co Inc Kenilworth NJ USA;

Merck &

Co Inc Kenilworth NJ USA;

Merck &

Co Inc Kenilworth NJ USA;

Merck &

Co Inc Kenilworth NJ USA;

Merck &

Co Inc Kenilworth NJ USA;

St Antoine Hosp Dept Hepatol Paris France;

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原文格式 PDF
正文语种 eng
中图分类内科学;
关键词
elbasvir; genotype 4; grazoprevir; hepatitis C; ribavirin;

机译：Elbasvir;基因型4;Grazoprevir;丙型肝炎;利巴韦林;

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专利

1. Efficacy of elbasvir and grazoprevir in participants with hepatitis C virus genotype 4 infection: A pooled analysis [J] . Asselah Tarik, Reesink Hendrik, Gerstoft Jan, Liver international : . 2018,第9期

机译：Elbasvir和Grazoprevir在丙型肝炎病毒基因型4感染的参与者中的疗效：汇总分析
2. The accuracy of baseline viral load for predicting the efficacy of elbasvir/grazoprevir in participants with hepatitis C virus genotype 1a infection: An integrated analysis [J] . Serfaty Lawrence, Jacobson Ira, Rockstroh Juergen, Journal of viral hepatitis. . 2019,第3期

机译：基线病毒载荷的准确性预测丙型肝炎病毒基因型1A感染参与者的Elbasvir / Grazoprevir的疗效：综合分析
3. A Pragmatic Approach to Optimizing the Efficacy of Elbasvir/Grazoprevir Using Baseline Viral Load in Participants With Hepatitis C Virus (HCV) Genotype (GT) 1a Infection: A Post Hoc Analysis of 11 Clinical Trials [J] . Serfaty Lawrence, Jacobson Ira, Rockstroh Jurgen K., Hepatology: Official Journal of the American Association for the Study of Liver Diseases . 2017,第Suppla1期

机译：在丙型肝炎病毒（HCV）基因型（GT）1A感染中使用基线病毒载体优化Elbasvir / Grazoprevir疗效的务实方法：11例临床试验的后HOC分析
4. Influence of hepatitis C virus genotypes and F protein on outcome of HCV infection among injection drug users [C] . Yun Zhang, Jingjing Yang, Haopeng Wang, International symposium on pharmacogenomics and the regulation of drug metabolism enzymes and genes. . 2010

机译：丙型肝炎病毒基因型和F蛋白对注射吸毒者HCV感染结局的影响
5. Hepatitis C infection in injection drug users from southern China: Low viral clearance, multiple genotypes and mixed genotype infections. [D] . Garten, Rebecca JoAnne. 2005

机译：中国南部注射吸毒者的丙型肝炎感染：病毒清除率低，多种基因型和混合基因型感染。
6. Grazoprevir and Elbasvir in Patients with Genotype 1 Hepatitis C Virus Infection: A Comprehensive Efficacy and Safety Analysis [O] . Yinan Yao, Ming Yue, Jie Wang, 2017

机译：Grazoprevir和Elbasvir在基因1型丙型肝炎病毒感染患者中的作用：全面的疗效和安全性分析
7. Grazoprevir and Elbasvir in Patients with Genotype 1 Hepatitis C Virus Infection: A Comprehensive Efficacy and Safety Analysis [O] . Yinan Yao, Ming Yue, Jie Wang, 2017

机译：Grazoprevir和Elbasvir在基因型1丙型肝炎病毒感染中的患者：综合疗效和安全分析

Efficacy of elbasvir and grazoprevir in participants with hepatitis C virus genotype 4 infection: A pooled analysis

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