Immune response to human telomerase reverse transcriptase-derived helper T cell epitopes in hepatocellular carcinoma patients

摘要

Background and Aims: Human telomerase reverse transcriptase is a catalytic enzyme involved in telomere elongation. It is expressed in many tumours, including hepatocellular carcinoma. The purpose of the present study was to identify major histocompatibility complex class II-restricted helper T cell epitopes derived from human telomerase reverse transcriptase in patients with hepatocellular carcinoma.