<i xmlns='http://www.wiley.com/namespaces/wiley'>In vitroIn vitro and <i xmlns='http://www.wiley.com/namespaces/wiley'>in vivoin vivo metabolic profiles of fasiglifam using ultrahigh‐performance liquid chromatography combined with Q‐Exactive Orbitrap tandem mass spectrometry

首页> 外文期刊>Rapid Communications in Mass Spectrometry: RCM >In vitroIn vitro and in vivoin vivo metabolic profiles of fasiglifam using ultrahigh‐performance liquid chromatography combined with Q‐Exactive Orbitrap tandem mass spectrometry

【24h】
In vitroIn vitro and in vivoin vivo metabolic profiles of fasiglifam using ultrahigh‐performance liquid chromatography combined with Q‐Exactive Orbitrap tandem mass spectrometry
展开▼

机译：体外和在体外和中使用超高性能液相色谱法与Q-辐射的液相色谱法相结合的Q-Exactive Orbitrap串联质谱法
展开▼

获取原文

获取原文并翻译 | 示例

免费外文文献都是OA文献，本网站仅为用户提供查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，请知悉并谅解

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

免费

页面导航

摘要

著录项

相似文献

相关主题

摘要

Rationale > Fasiglifam is an orally available and selective partial agonist of hGPR40 receptor, which was unexpectedly terminated at phase III clinical trials due to its severe hepatotoxicity. To fully understand the mechanism of action of fasiglifam, it is necessary to investigate its in vitro and in vivo metabolic profiles. </section> <section xml:id="rcm8174-sec-0002" numbered="no"> <title type="main">Methods > For in vitro metabolism, fasiglifam was incubated with rat or human liver microsomes in the presence of β‐nicotinamide adenine dinucleotide phosphate tetrasodium salt, glutathione (GSH) and uridine diphosphate glucuronic acid trisodium salt for 60?min. For in vivo metabolism, fasiglifam was orally administered to rats at a single dose of 20?mg/kg and the bile was collected. In vitro and in vivo samples were analyzed by the developed ultrahigh‐performance liquid chromatography combined with Q‐Exactive Orbitrap tandem mass spectrometry. The structures of metabolites were proposed according to their accurate masses and fragment ions. </section> <section xml:id="rcm8174-sec-0003" numbered="no"> <title type="main">Results >A total of eight metabolites, including an acyl‐GSH adduct, were detected and identified. M1 (acylglucuronide) and M5 (carboxylic acid derivative) were the major metabolites of fasiglifam. Metabolic pathways of fasiglifam involved oxygenation, oxidative dealkylation, dehydrogenation, glucuronidation and GSH conjugation. Fasiglifam may undergo metabolic </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract XMLNS =“http://www.wiley.com/namespaces/wiley”type =“main”xml：lang =“en”> <section xml：id =“rcm8174-sec-0001”编号=“否” > <标题类型=“main”>基本原理</标题> > fasiglifam是HGPR40受体的口服和选择性部分激动剂，其由于其严重的肝毒性而在第III期临床试验中出乎意料地终止。为了充分了解Fasiglifam的作用机制，有必要在体内的体外研究，在体外的型中的代谢谱中。 </ p> </ section> <section xml：id =“rcm8174-sec-0002”编号=“否”> <title type =“main”>方法</ title> >对于在体外< / i>新陈代谢，在β-烟酰胺腺嘌呤二核苷酸磷酸四胞盐，谷胱甘肽（GSH）和尿苷二磷酸葡糖醛酸三钠盐中，将Fasiglifam与大鼠或人肝微粒体一起温育或人肝微粒体。对于vivo </ i>新陈代谢的，将Fasiglifam口服给予单剂量为20℃/ kg的大鼠，并收集胆汁。通过显影的超高性能液相色谱法与Q-Exactive orbitrap串联质谱分析，分析了体内的体外</ i>和。根据其精确的质量和片段离子提出代谢物的结构。 </ p> </ section> <section xml：id =“rcm8174-sec-0003”编号=“否”> <标题类型=“main”>结果</ title> >总共八个代谢物，包括检测并鉴定acyl-gsh加合物。 M1（酰基葡萄糖酰胺）和M5（羧酸衍生物）是Fasiglifam的主要代谢物。 Fasiglifam的代谢途径涉及氧合，氧化脱烷基化，脱氢，葡糖醛酸化和GSH缀合。 Fasiglifam可能经历代谢 </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-26627/'>《Rapid Communications in Mass Spectrometry: RCM》</a> <b style="margin: 0 2px;">|</b><span>2018年第16期</span><b style="margin: 0 2px;">|</b><span>共9页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Li Jin‐Qi&option=202" target="_blank" rel="nofollow">Li Jin‐Qi;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Li Jie&option=202" target="_blank" rel="nofollow">Li Jie;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Wang Jia‐Feng&option=202" target="_blank" rel="nofollow">Wang Jia‐Feng;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zhang Shu‐han&option=202" target="_blank" rel="nofollow">Zhang Shu‐han;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=He Dan&option=202" target="_blank" rel="nofollow">He Dan;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Yong Rong‐Sheng&option=202" target="_blank" rel="nofollow">Yong Rong‐Sheng;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=She Shu‐Ya&option=202" target="_blank" rel="nofollow">She Shu‐Ya;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Sichuan Academy of Medical Science and Sichuan Provincial People's HospitalChengdu 610072 China;</p> <p>School of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 610054 China;</p> <p>School of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 610054 China;</p> <p>School of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 610054 China;</p> <p>School of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 610054 China;</p> <p>Sichuan Academy of Medical Science and Sichuan Provincial People's HospitalChengdu 610072 China;</p> <p>Sichuan Academy of Medical Science and Sichuan Provincial People's HospitalChengdu 610072 China;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/1187.html" title="分析化学">分析化学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> </p> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704024020570.html"><i xmlns="http://www.wiley.com/namespaces/wiley">In vitroIn vitro and <i xmlns="http://www.wiley.com/namespaces/wiley">in vivoin vivo metabolic profiles of fasiglifam using ultrahigh‐performance liquid chromatography combined with Q‐Exactive Orbitrap tandem mass spectrometry</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Li Jin‐Qi&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Li Jin‐Qi,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Li Jie&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Li Jie,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Wang Jia‐Feng&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Wang Jia‐Feng,</a> <a href="/journal-foreign-26627/" target="_blank" rel="nofollow" class="tuijian_authcolor">Rapid Communications in Mass Spectrometry: RCM .</a> <span>2018</span><span>,第16期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：<i xmlns =“http://www.wiley.com/namespaces/wiley”>体外和</ i>在体外和<i xmlns =“http://www.wiley.com/namespaces/wiley”>中使用超高性能液相色谱法与Q-辐射的液相色谱法相结合的Q-Exactive Orbitrap串联质谱法</span> </p> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704025633271.html">Modified proton transfer reaction mass spectrometry (PTR‐MS) operating conditions for <i xmlns="http://www.wiley.com/namespaces/wiley">in vitroin vitro and <i xmlns="http://www.wiley.com/namespaces/wiley">in vivoin vivo analysis of wine aroma</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Sémon Etienne&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Sémon Etienne,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Arvisenet Ga?lle&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Arvisenet Ga?lle,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Guichard Elisabeth&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Guichard Elisabeth,</a> <a href="/journal-foreign-34906/" target="_blank" rel="nofollow" class="tuijian_authcolor">Journal of mass spectrometry: JMS .</a> <span>2018</span><span>,第1期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：修改的质子传递反应质谱（PTR-MS）为<i XMLNS =“http://www.wiley.com/namespaces/wiley”>在体外和<i xmlns =“http：http： //www.wiley.com/namespaces/wiley" posin vivo </ i>在葡萄酒香气的体内分析中</span> </p> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704024826607.html"><i xmlns="http://www.wiley.com/namespaces/wiley">In vitroIn vitro and <i xmlns="http://www.wiley.com/namespaces/wiley">in vivoin vivo gene delivery using chitosan/hyaluronic acid nanoparticles: Influences of molecular mass of hyaluronic acid and lyophilization on transfection efficiency</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Sato Toshinori&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Sato Toshinori,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Nakata Mitsuhiro&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Nakata Mitsuhiro,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Yang Zhihong&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Yang Zhihong,</a> <a href="/journal-foreign-30882/" target="_blank" rel="nofollow" class="tuijian_authcolor">The journal of gene medicine .</a> <span>2017</span><span>,第8期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：<i xmlns =“http://www.wiley.com/namespaces/wiley”>体外和</ i>在体外和<i xmlns =“http://www.wiley.com/namespaces/wiley”>中使用壳聚糖/透明质酸纳米粒子的体内基因递送的体内递送：透明质酸分子量和冻干对转染效率的影响</span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/academic-conference-foreign_meeting-256173_thesis/0705011192455.html">In-Vitro Metabolic Stability and Profiling of Ponatinib, Vandetanib and Masitinib using Liquid Chromatography Tandem Mass Spectrometry</a> <b>[C]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Adnan Kadi&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Adnan Kadi,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Sawsan Amer&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Sawsan Amer,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Hany Darwish&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Hany Darwish,</a> <a href="/conference-foreign-256173/" target="_blank" rel="nofollow" class="tuijian_authcolor">ASMS Conference on Mass Spectrometry and Allied Topics .</a> <span>2016</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：使用液相色谱串联质谱法的体外代谢稳定性和Ponatinib，Vandetanib和Masitinib的剖析</span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/academic-degree-foreign_mphd_thesis/02061657705.html">High performance liquid chromatography with tandem laser induced fluorescence and mass spectrometry detection methods to monitor the metabolic profile of doxorubicin and its alteration with age</a> <b>[D] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Katzenmeyer, Joseph Bradly&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Katzenmeyer, Joseph Bradly </a> <span>2010</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：高效液相色谱-串联激光诱导荧光和质谱检测方法监测阿霉素的代谢情况及其随年龄的变化</span> </p> </li> <li> <div> <b>6. </b><a class="enjiyixqcontent" href="/academic-journal-foreign-pmc_detail_thesis/040006111047.html">Correction to Supercritical CO2 Fluid Extractionfor the Identification of Compounds from Citrusreticulata Semen by Ultra-High-Performance Liquid Chromatography Combinedwith Q-Exactive Orbitrap Tandem Mass Spectrometry</a> <b>[O] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Guodong Zheng&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Guodong Zheng,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Xiujuan Yang&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Xiujuan Yang,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Mengshi Liu&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Mengshi Liu,</a> <span>2020</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：对超临界二氧化碳流体萃取的修正柑橘中化合物的鉴定超高效液相色谱法测定网纹精液Q-Exactive Orbitrap串联质谱分析仪</span> </p> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/open-access_resources_thesis/01000132479265.html">An Entire Process Optimization Strategy for Comprehensive In Vivo Metabolite Profiling of Prucalopride in Rats Based on Ultra-Performance Liquid Chromatography With Q-Exactive Hybrid Quadrupole–Orbitrap High-Resolution Mass Spectrometry</a> <b>[O] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Lihua Zuo&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Lihua Zuo,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Liwei Liu&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Liwei Liu,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Yantao Yang&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Yantao Yang,</a> <span>2021</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：基于超高效液相色谱法的Q-Axactive Hybrid Quadruprole-orbitrap高分辨率质谱法综合体内综合综合处理优化策略</span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" id="enpatent55">相关主题</h3> <ul id="subject"> </ul> </div> </div> </div> </div> <div class="right rightcon"> <div class="details_img cardcommon clearfix" style="margin-bottom: 10px;display:none;" > </div> </div> </div> <div id="thesis_get_original1" class="downloadBth" style="bottom: 19px;z-index: 999;" onclick="ywcd('0704024020570','4',7,2,1,'',this,24)" class="delivery" prompt="010401" title="通过人工服务将文献原文发送至邮箱" >获取原文</div> <div class="journalsub-pop-up" style="display: none"> <div class="journal-sub"> <h2>期刊订阅</h2> <img src="https://cdn.zhangqiaokeyan.com/img/loginclose.png" alt="" onclick="$('.journalsub-pop-up').hide()"> <p class="pardon">抱歉，该期刊暂不可订阅，敬请期待！</p> <p class="current">目前支持订阅全部北京大学中文核心（2020）期刊目录。</p> <div style="display: flex;margin-top: 69px;justify-content: space-between;"> <div class="no-sub" onclick="$('.journalsub-pop-up').hide()">暂不订阅</div> <div class="other-sub" onclick="continueSub('from=pc-detail')">继续订阅其他期刊</div> </div> </div> </div> <div class="right_btn"> <ul> <li class="gouwuche">  </li> <li class="yijian"> <a href="javascript:void(0);" onclick="link_analysis('/mycenter/auth/complaint.html',this)">意见反馈</a> </li> <li class="top"> <a href="javascript:scrollTo(0,0);">回到顶部</a> </li> <li class="shouye"> <a href="/">回到首页</a> </li> </ul> </div> <div class="xllindexfooter"> <div class="xllindexfootercenter"> <div class="xllindexfooterleft left" > <div class="xllindexfooterleftli"> <ul> <li><a href="/about.html">关于掌桥</a></li> <li><a href="/help/helpmap.html">资源导航</a></li> <li><a href="/help/helpguide.html">新手指南</a></li> <li><a href="/help/helpcenter.html">常见问题</a></li> <li><a href="/sitemap.html">网站地图</a></li> <li><a href="/help/helpcenter.html?type=9">版权声明</a></li> </ul> </div> <div class="xllindexfooterleft"> <p class="xllindexfooterlefteamil">客服邮箱：kefu@zhangqiaokeyan.com</p> <div class="xllindexfooterlefttcp"> <div class="xllindexfooterpoliceiimg"></div> <div class="xllindexfooterpoliceispan"> <span>京公网安备：11010802029741号 </span> <span>ICP备案号：<a href="https://beian.miit.gov.cn" rel="nofollow" target="_blank">京ICP备15016152号-6</a></span> <span>六维联合信息科技 (北京) 有限公司©版权所有</span> </div> </div> </div> </div> <div class="xllindexfooterright left"> <ul> <li> <p style="font-weight: bold;">客服微信</p> <div></div> </li> <li> <p style="font-weight: bold;">服务号</p> <div></div> </li> </ul> </div> </div> </div> <span id="0704024020570down" data-source="7," data-out-id="LSg4PkMVzqlY4PhJEX7YlQ==," data-f-source-id="7" data-title="<i xmlns='http://www.wiley.com/namespaces/wiley'>In vitroIn vitro and <i xmlns='http://www.wiley.com/namespaces/wiley'>in vivoin vivo metabolic profiles of fasiglifam using ultrahigh‐performance liquid chromatography combined with Q‐Exactive Orbitrap tandem mass spectrometry" data-price="20" data-site-name="" data-transnum="24" style="display:none;"></span> <input type="hidden" value="4" id="sourcetype"> <input type="hidden" value="26627" id="journalid"> <input type="hidden" value="1" id="inyn_provide_service_level"> <input type="hidden" value="https://cdn.zhangqiaokeyan.com" id="imgcdn"> <input type="hidden" value="1" id="isdeatail"> <input type="hidden" value="" id="syyn_indexed_database"> <input type="hidden" value="" id="servicetype"> <input type="hidden" id="pagename" value="<i xmlns='http://www.wiley.com/namespaces/wiley'>In vitroIn vitro and <i xmlns='http://www.wiley.com/namespaces/wiley'>in vivoin vivo metabolic profiles of fasiglifam using ultrahigh‐performance liquid chromatography combined with Q‐Exactive Orbitrap tandem mass spectrometry"/> <input type="hidden" value="thesis_get_original" id="pageIdentification"> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/jquery-1.12.4.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/lwlh_ajax.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/zq.js?v=5.7.7"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/common.js?v=5.7.7"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/jquery.cookie.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/top.js?v=5.7.7"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/tip.js?v=5.7.7"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/login.js?v=5.7.7"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/down.js?v=5.7.7"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/search.js?v=5.7.7"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/searchtype.js?v=5.7.7"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/user/regist.js?v=5.7.7"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/zxs_solor/detail.js?v=5.7.7"></script> <script type="text/javascript" src="https://www.zhangqiaokeyan.com/statistics/static/pagecollection.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/tj.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/pushbaidu.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/history.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/util/cookie.js?v=5.7.7"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/weipu/weipu.js?v=5.7.7"></script> </body> <script> $(function(){ var weiPuStatus = getCookie('WeiPuStatus'); if(weiPuStatus){ tipWeiPuStatus(weiPuStatus); delCookie('WeiPuStatus'); } getFacetKeywordVoInId(); var sourcetype = $("#sourcetype").val(); var inyn_provide_service_level = $("#inyn_provide_service_level").val(); if((sourcetype ==1||sourcetype==4)&&inyn_provide_service_level!=4){ getJournal(); } }) </script> </html>

In vitroIn vitro and in vivoin vivo metabolic profiles of fasiglifam using ultrahigh‐performance liquid chromatography combined with Q‐Exactive Orbitrap tandem mass spectrometry

摘要