Remote sampling mass spectrometry for dry samples: Sheath‐flow probe electrospray ionization (PESI) using a gel‐loading tip inserted with an acupuncture needle

Usmanov Dilshadbek T.; Ashurov Khatam B.; Ninomiya Satoshi; Hiraoka Kenzo; Wada Hiroshi; Nakano Hiroshi; Matsumura Masaya; Sanada‐Morimura Sachiyo; Nonami Hiroshi

摘要

Rationale >Probe electrospray ionization (PESI) is only applicable to liquid or wet samples. In this study, a sheath‐flow PESI method for remote sampling mass spectrometry that can be applied to dry samples was developed. </section> <section xml:id="rcm8045-sec-0002" numbered="no"> <title type="main">Methods >An acupuncture needle (0.12?mm outer diameter, 700?nm tip diameter) was inserted into a gel‐loading tip with a 0.1?mm protrusion out of the tip. Analytes were extracted by filling the latter tip with solvent and softly touching the sample surface for a short time (1?s). A high voltage was applied to the acupuncture needle, and mass spectra of analytes were obtained by self‐aspirating electrospray. </section> <section xml:id="rcm8045-sec-0003" numbered="no"> <title type="main">Results >Dry samples, such as lines of ballpoint pen ink on paper, pharmaceutical tablets, instant coffee, brown rice, and narcotics, gave strong ion signals. The sample carryover was negligible. The sequential electrospray was observed to be similar to conventional PESI. The limits of detection (LODs) for morphine and rhodamine B were found to be of the order of picograms. </section> <section xml:id="rcm8045-sec-0004" numbered="no"> <title type="main">Conclusions >Because of its simplicity and versatility, sheath‐flow PESI is a promising technique for on‐site and nondestructive profile analysis of dry samples with bulky and complicated shapes, with a spatial resolution of ~0.3?mm. </section> </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract XMLNS =“http://www.wiley.com/namespaces/wiley”type =“main”xml：lang =“en”> <section xml：id =“rcm8045-sec-0001”编号=“否” > <标题类型=“main”>基本原理</标题> >探针电喷雾电离（Pesi）仅适用于液体或湿式样品。在该研究中，开发了一种用于远程采样质谱法的鞘流PESI方法，其可以应用于干燥样品。</ p> </段> <部分XML：ID =“RCM8045-SEC-0002”编号=“NO “> <标题类型=”main“>方法</标题> >将针刺针（0.12×mm外径，700×nm直径）插入凝胶装载尖端，其中突起为0.1ΩΩmm小费。通过用溶剂填充后一尖端并轻轻地触摸样品表面，萃取分析物，使样品表面短时间（＆1μl）。将高电压施加到针灸针上，通过自吸电喷雾获得分析物的质谱。</ p> </ section> <secto XML：ID =“RCM8045-SEC-0003”编号=“否”> <标题类型=“main”>结果</标题> >干燥样品，如纸上的圆珠笔墨水，药物片剂，速溶咖啡，糙米和毒品，给出了强的离子信号。样品携带可忽略不计。观察到顺序电喷雾与常规Pesi类似。发现吗啡和罗丹明B的检测限率为PicoChars的顺序。</ p> </ section> <secto XML：ID =“RCM8045-SEC-0004”编号=“否”> <标题类型=“main”>结论</ title> >由于其简单性和多功能性，Sheath-Flow Pesi是一种有希望的现场和非破坏性概况分析的有希望的干燥样品，具有庞大和复杂的形状，具有空间分辨率〜0.3Ωmm。</ p> </ section> </ abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-26627/'>《Rapid Communications in Mass Spectrometry: RCM》</a> <b style="margin: 0 2px;">|</b><span>2018年第5期</span><b style="margin: 0 2px;">|</b><span>共7页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Usmanov Dilshadbek T.&option=202" target="_blank" rel="nofollow">Usmanov Dilshadbek T.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ashurov Khatam B.&option=202" target="_blank" rel="nofollow">Ashurov Khatam B.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ninomiya Satoshi&option=202" target="_blank" rel="nofollow">Ninomiya Satoshi;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Hiraoka Kenzo&option=202" target="_blank" rel="nofollow">Hiraoka Kenzo;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Wada Hiroshi&option=202" target="_blank" rel="nofollow">Wada Hiroshi;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Nakano Hiroshi&option=202" target="_blank" rel="nofollow">Nakano Hiroshi;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Matsumura Masaya&option=202" target="_blank" rel="nofollow">Matsumura Masaya;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Sanada‐Morimura Sachiyo&option=202" target="_blank" rel="nofollow">Sanada‐Morimura Sachiyo;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Nonami Hiroshi&option=202" target="_blank" rel="nofollow">Nonami Hiroshi;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Clean Energy Research CenterUniversity of Yamanashi4‐3‐11 Takeda Kofu Yamanashi 400‐8511 Japan;</p> <p>Institute of Ion‐Plasma and Laser TechnologiesDurmon Yoli Street 33 100125 Tashkent Uzbekistan;</p> <p>Graduate School Department of Interdisciplinary ResearchUniversity of Yamanashi4‐3‐11 Takeda Kofu 400‐8511 Japan;</p> <p>Clean Energy Research CenterUniversity of Yamanashi4‐3‐11 Takeda Kofu Yamanashi 400‐8511 Japan;</p> <p>Kyushu Okinawa Agricultural Research CenterNational Agriculture and Food Research Organization496 Izumi Chikugo Fukuoka 833‐0041 Japan;</p> <p>Kyushu Okinawa Agricultural Research CenterNational Agriculture and Food Research Organization496 Izumi Chikugo Fukuoka 833‐0041 Japan;</p> <p>Kyushu Okinawa Agricultural Research CenterNational Agriculture and Food Research OrganizationSuya 2421 Goshi Kumamoto 861‐1192 Japan;</p> <p>Kyushu Okinawa Agricultural Research CenterNational Agriculture and Food Research OrganizationSuya 2421 Goshi Kumamoto 861‐1192 Japan;</p> <p>Plant Biophysics/Biochemistry Research Laboratory Faculty of AgricultureEhime UniversityMatsuyama 790‐8566 Japan;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/1187.html" title="分析化学">分析化学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> </p> </li> </ul> </div> </div> <div class="literature cardcommon" id="literaturereference" style="display:none"> <div class="similarity "> <h3 class="all_title" id="enpatent111">引文网络</h3> <div class="referencetab clearfix"> <ul id="referencedaohang"> <li dataid="referenceul">参考文献</li> <li dataid="citationul">引证文献</li> <li dataid="commonreferenceul">共引文献</li> <li dataid="commoncitationul">同被引文献</li> <li dataid="tworeferenceul">二级参考文献</li> <li dataid="twocitationul">二级引证文献</li> </ul> </div> <div 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