Continuous-flow crystallisation in 3D-printed compact devices

摘要

A flexible and cost-effective methodology to develop compact flow devices with heat exchange ability is presented here. Additive manufacturing techniques allow the rapid design and manufacture of modular jacketed flow devices, where heat exchange can be modelled and controlled to generate efficient devices for applications in continuous-flow cooling crystallisation. As a proof of concept, the crystallisation of para- cetamol has been demonstrated. The manufactured devices are effective in crystallising form II paraceta- mol employing metacetamol as a co-crystallising agent.