Enhancement Antimicrobial Activity of Clarithromycin by Amine Functionalized Mesoporous Silica Nanoparticles as Drug Delivery System

Khosravian Pegah; Khoobi Mehdi; Ardestani Mehdi Shafiee; Daryasari Mohammad Porgham; Hassanzadeh Malihe; Ghasemi-Dehkordi Payam; Amanlou Massoud; Javar Hamid Akbari

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Enhancement Antimicrobial Activity of Clarithromycin by Amine Functionalized Mesoporous Silica Nanoparticles as Drug Delivery System

机译：胺官能化介孔二氧化硅纳米粒子的增强碳霉素作为药物递送系统的增强抗菌活性

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Background: Nano-drug delivery systems as mesoporous silica nanoparticles ( MSNs) with unique properties have the potential to improve drug efficacy. The purpose of the present study was to design of CLM loaded MSNs-NH2 to improve the physicochemical properties and antibacterial activity with enhancement delivery to infected tissues.

机译：背景：纳米药物递送系统作为中孔二氧化硅纳米颗粒（MSN），具有独特性质具有可提高药物功效的潜力。本研究的目的是设计CLM负载MSNS-NH2，以改善具有增强递送的物理化学性质和抗菌活性与受感染组织。

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来源
《Letters in drug design & discovery》 |2018年第7期|共9页
作者
Khosravian Pegah; Khoobi Mehdi; Ardestani Mehdi Shafiee; Daryasari Mohammad Porgham; Hassanzadeh Malihe; Ghasemi-Dehkordi Payam; Amanlou Massoud; Javar Hamid Akbari;
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作者单位

Shahrekord Univ Med Sci Basic Hlth Sci Inst Med Plants Res Ctr Shahrekord Iran;

Univ Tehran Med Sci Fac Pharm Dept Pharmaceut Biomat Tehran Iran;

Univ Tehran Med Sci Fac Pharm Dept Radiopharm Tehran Iran;

Islamic Azad Univ Kerman Branch Dept Chem Kerman Iran;

Univ Tehran Med Sci Fac Pharm Dept Med Chem Tehran Iran;

Shahrekord Univ Med Sci Basic Hlth Sci Inst Cellular &

Mol Res Ctr Shahrekord Iran;

Univ Tehran Med Sci Fac Pharm Dept Med Chem Tehran Iran;

Univ Tehran Med Sci Fac Pharm Dept Pharmaceut Postal Box 14155-6451 Tehran Iran;

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原文格式 PDF
正文语种 eng
中图分类生药学（天然药物学）;
关键词
Drug delivery; mesoporous silica nanoparticle; clarithromycin; antimicrobial activity; TEM; SEM;

机译：药物递送;中孔硅纳米粒子;克拉霉素;抗菌活性;TEM;SEM;

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专利

1. Enhancement Antimicrobial Activity of Clarithromycin by Amine Functionalized Mesoporous Silica Nanoparticles as Drug Delivery System [J] . Khosravian Pegah, Khoobi Mehdi, Ardestani Mehdi Shafiee, Letters in drug design & discovery . 2018,第7期

机译：胺官能化介孔二氧化硅纳米粒子的增强碳霉素作为药物递送系统的增强抗菌活性
2. Amine functionalized cubic mesoporous silica nanoparticles as an oral delivery system for curcumin bioavailability enhancement [J] . Hartono Sandy Budi, Hadisoewignyo Lannie, Yang Yanan, Nanotechnology . 2016,第50期

机译：胺官能化立方中孔二氧化硅纳米粒子作为姜黄素生物利用度增强的口服递送系统
3. Amine functionalized cubic mesoporous silica nanoparticles as an oral delivery system for curcumin bioavailability enhancement [J] . Hartono Sandy Budi, Hadisoewignyo Lannie, Yang Yanan, Nanotechnology . 2016,第50期

机译：胺官能化的立方介孔二氧化硅纳米颗粒作为口服递送系统，可增强姜黄素的生物利用度
4. Functionalization of Mesoporous Silica Nanoparticles with efficient Endosomal Escape for Cancer Targeted Drug Delivery [C] . Beatrice Fortuni, Monica Ricci, Rocha Susana 日本化学会春季年会講演予稿集 . 2018

机译：中孔二氧化硅纳米粒子的官能化癌症靶向药物递送的有效内体逸出
5. Functionalized mesoporous silica nanoparticles (MSNs) for applications in drug delivery and catalysis. [D] . Huang, Wei. 2010

机译：功能化的介孔二氧化硅纳米粒子（MSN），用于药物递送和催化。
6. In vivo tumor suppression efficacy of mesoporous silica nanoparticles-based drug delivery system: enhanced efficacy by folate modification [O] . Jie Lu, Zongxi Li, Jeffrey I. Zink, -1

机译：在介孔二氧化硅纳米粒子的药物递送系统的体内肿瘤抑制效果：叶酸改性的增强效力
7. Amine functionalized cubic mesoporous silica nanoparticles as an oral delivery system for curcumin bioavailability enhancement [O] . Sandy Budi Hartono, Lannie Hadisoewignyo, Yanan Yang, 2016

机译：胺官能化立方中孔二氧化硅纳米粒子作为姜黄素生物利用度增强的口服递送系统

Enhancement Antimicrobial Activity of Clarithromycin by Amine Functionalized Mesoporous Silica Nanoparticles as Drug Delivery System

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