Commentary on 'Additional information from chromosomal microarray analysis (CMA). over conventional karyotyping when diagnosing chromosomal abnormalities in miscarriage: A systematic review and meta-analysis'

摘要

The meta-analysis described by Dhillon et al. has shown that chromosomal microarrays (CMAs) detected 13% more genetic abnormalities than conventional karyotyping of the abortus. CMA easily identifies aneuploidy, unbalanced translocations, deletions, and duplications; however, balanced translocations, haploidy, or polyploidy cannot be detected. Indeed, as described by Dhillon et al., traditional karyotyping detected 3% additional abnormalities that were not detected by CMA. Therefore, for a complete picture, it may be necessary to perform a standard karyotype in addition to CMA.