Daily therapy with a slow-releasing H2S donor GYY4137 enables early functional recovery and ameliorates renal injury associated with urinary obstruction

Lin Shouzhe; Lian Dameng; Liu Weihua; Haig Aaron; Lobb Ian; Hijazi Ahmed; Razvi Hassan; Burton Jeremy; Whiteman Matthew; Sener Alp

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Daily therapy with a slow-releasing H2S donor GYY4137 enables early functional recovery and ameliorates renal injury associated with urinary obstruction

机译：具有缓慢释放的H2S供体Gyy4137的日常治疗使得能够早期功能恢复和改善与泌尿阻塞相关的肾损伤

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Objectives: To assess the effects of slow-releasing H2S donor GYY4137 on post-obstructive renal function and injury following unilateral ureteral obstruction (UUO) by using the UUO and reimplantation (UUO-R) model in rats and to elucidate potential mechanisms by using an in vitro model of epithelial-mesenchymal transition (EMT).

机译：目的：通过使用大鼠UUO和再普遍（UUO-R）模型来评估缓慢释放H2S供体Gyy4137对单侧输尿管梗阻（UUO）后梗阻后肾功能和损伤的影响，并通过使用阐明潜在机制上皮 - 间充质转换的体外模型（EMT）。

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来源
《Nitric oxide: Biology and chemistry》 |2018年第2018期|共13页
作者
Lin Shouzhe; Lian Dameng; Liu Weihua; Haig Aaron; Lobb Ian; Hijazi Ahmed; Razvi Hassan; Burton Jeremy; Whiteman Matthew; Sener Alp;
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作者单位

Western Univ Dept Microbiol &

Immunol London ON Canada;

London Hlth Sci Ctr Matthew Mailing Ctr Translat Transplant Studies London ON Canada;

Western Univ Dept Pathol London ON Canada;

Western Univ Dept Pathol London ON Canada;

Western Univ Dept Microbiol &

Immunol London ON Canada;

Western Univ Schulich Sch Med &

Dent London ON Canada;

Western Univ Dept Surg London ON Canada;

Western Univ Dept Microbiol &

Immunol London ON Canada;

Univ Exeter Med Sch Exeter Devon England;

Western Univ Dept Microbiol &

Immunol London ON Canada;

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原文格式 PDF
正文语种 eng
中图分类第Ⅴ族元素及其化合物;生物物理学;
关键词
Unilateral ureteral obstruction; Hydrogen sulfide; Renal function; Renal injury; Epithelial mesenchymal transition; Transforming growth factor beta 1;

机译：单侧输尿管梗阻;硫化氢;肾功能;肾损伤;上皮间充质转换;转化生长因子β1;

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专利

1. Daily therapy with a slow-releasing H2S donor GYY4137 enables early functional recovery and ameliorates renal injury associated with urinary obstruction [J] . Lin Shouzhe, Lian Dameng, Liu Weihua, Nitric oxide: Biology and chemistry . 2018,第期

机译：具有缓慢释放的H2S供体Gyy4137的日常治疗使得能够早期功能恢复和改善与泌尿阻塞相关的肾损伤
2. GYY4137, a Slow-Releasing Hydrogen Sulfide Donor, Ameliorates Renal Damage Associated with Chronic Obstructive Uropathy [J] . Lin Shouzhe, Visram Fazil, Liu Weihua, The Journal of Urology . 2016,第6期

机译：GYY4137，缓慢释放的硫化氢供体，可减轻与慢性阻塞性尿路病相关的肾脏损害
3. H2S donor GYY4137 ameliorates paclitaxel-induced neuropathic pain in mice [J] . Biomedicine & pharmacotherapy =: Biomedecine & pharmacotherapie . 2020,第期

机译：H2S供体Gyy4137改善紫杉醇诱导的小鼠神经病疼痛
4. GYY4137 an H2S Slow-Releasing Donor Prevents Nitrative Stress and α-Synuclein Nitration in an MPTP Mouse Model of Parkinson’s Disease [O] . Xiaoou Hou, Yuqing Yuan, Yulan Sheng, 2017

机译：HYY缓释供体GYY4137可预防帕金森氏病MPTP小鼠模型中的硝化应激和α-突触核蛋白的硝化
5. GYY4137, a slow-releasing hydrogen sulfide donor, ameliorates renal damage associated with chronic obstructive uropathy. [O] . Lin, S, Visram, F, Liu, W, 2016

机译：GYY4137是一种缓慢释放的硫化氢供体，可缓解与慢性阻塞性尿毒症有关的肾脏损害。
6. Adjunctive Therapy to Improve Functional Recovery after Limb Ischemia Reperfusion Injury. [R] . Crawford, R. 2017

机译：辅助治疗改善肢体缺血再灌注损伤后功能恢复。

Daily therapy with a slow-releasing H2S donor GYY4137 enables early functional recovery and ameliorates renal injury associated with urinary obstruction

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