Lnc RNA FENDRR RNA FENDRR attenuates adriamycin resistance via suppressing MDR MDR 1 expression through sponging HuR and miR‐184 in chronic myelogenous leukaemia cells

摘要

Chemotherapy is a major anticancer therapeutic modality, however, multidrug resistance ( MDR ) is frequently observed and hinders treatment efficacy. Here, we investigated the role and potential mechanism of the long noncoding RNA (lnc RNA ) F ENDRR in adriamycin resistance of chronic myeloid leukaemia ( CML ) cells. FENDRR overexpression attenuates adriamycin resistance, as shown by increased Rhodamine 123 accumulation, promotion of cell apoptosis in?vitro and suppression of tumour growth in?vivo . Mechanistically, we identified that FENDRR reduces the interaction of the RNA ‐binding protein HuR with MDR 1 via acting as a sponge, and miR‐184 competitively binds to FENDRR with HuR. Thus, the HuR/ FENDRR /miR‐184 interaction contributes to MDR 1 activity. These findings indicate that FENDRR is a potential target for reversing adriamycin resistance.