Effect of borneol as a penetration enhancer on brain targeting of nanoliposomes: facilitate direct delivery to neurons

摘要

Aim: This study is aimed to evaluate borneol as a penetration enhancer to improve brain target of nanoliposome. Materials & methods: Effects of borneol on pharmacokinetics, targeting efficiency, brain subareas distribution and neuron-targeting level and pathway were studied by fluorescence spectrophotometry and immunofluorescence. Results: Borneol did not influence physicochemical property of doxorubicin hydrochloride nanoliposome (Dox-nanoLips). Co-administration of Dox-nanoLips with borneol elevated brain-target efficiency due to selective distribution increase in the cerebral cortex and hippocampus without difference in contralateral hemisphere. Borneol improved neuronal-targeting level of Dox-nanoLips in the cortex, CA3 and dentate gyrus regions via opening tight junctions of blood-brain barrier and then bypassing astrocyte. Conclusion: Borneol is potential to be a promising penetration enhancer for nanocarrier to target neurons.