Ga-68-DOTATOC PET/CT in the localization of head and neck paraganglioma compared with F-18-DOPA PET/CT and I-123-MIBG SPECT/CT

摘要

Purpose: F-18-Fluoro-L-dihydroxyphenylalanine (F-18-DOPA) PET offers high sensitivity and specificity in the imaging of non-malignant head and neck paraganglioma (HNPGL) but lower sensitivity in metastatic disease of these neuroendocrine tumours (NET). In contrast to the radiotracer F-18-DOPA, both I-123-meta-iodo-benzylguanidine (I-123-MIBG) and Ga-68-DOTA-Tyr3-octreotide (Ga-68-DOTA-TOC) offer valuable clinical information on norepinephrine and somatostatin (SST) receptor status for planning I-131-MIBG and radionuclide peptide therapy (PRRT), respectively.