PET measurement of 'GABA shift' in the rat brain: A preclinical application of bolus plus constant infusion paradigm of [F-18]flumazenil

Kim Wook; Park Hyun Soo; Moon Byung Seok; Lee Byung Chul; Kim Sang Eun

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PET measurement of 'GABA shift' in the rat brain: A preclinical application of bolus plus constant infusion paradigm of [F-18]flumazenil

机译：宠物脑中“GABA换档”的宠物测量：推注Plus恒定输液范式的临床前应用[F-18]氟藏

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Introduction: We measured the tiagabine-induced enhancement of the GABA(A) receptor's affinity for benzodiazepine ligands ("GABA shift") using [F-18]flumazenil (FMZ) PET with preclinical application of bolus plus constant infusion (B/I). Differences in quantified results of [F-18]FMZ binding were compared to that of [F-18]FMZ PET with single bolus injection (SB).

机译：介绍：我们测量了使用[F-18] Flumazenil（FMZ）PET的苯二氮卓（FMZ）PET对苯二氮卓（FMZ）PET的苯并二氮卓（FMZ）的亲和力的增强促进噻吩（A）受体的亲和力（B / I）。将[F-18] FMZ结合的定量结果的差异与单引出单引发剂注射（Sb）的[F-18] FMZ PET的差异进行了比较。

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来源
《Nuclear Medicine and Biology》 |2017年第2017期|共5页
作者
Kim Wook; Park Hyun Soo; Moon Byung Seok; Lee Byung Chul; Kim Sang Eun;
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作者单位

Seoul Natl Univ Grad Sch Convergence Sci &

Technol Dept Transdisciplinary Studies 1 Gwanak Ro;

Seoul Natl Univ Bundang Hosp Coll Med Dept Nucl Med 300 Gumi Dong Seongnam 463707 South Korea;

Seoul Natl Univ Bundang Hosp Coll Med Dept Nucl Med 300 Gumi Dong Seongnam 463707 South Korea;

Seoul Natl Univ Bundang Hosp Coll Med Dept Nucl Med 300 Gumi Dong Seongnam 463707 South Korea;

Seoul Natl Univ Grad Sch Convergence Sci &

Technol Dept Transdisciplinary Studies 1 Gwanak Ro;

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原文格式 PDF
正文语种 eng
中图分类放射医学;
关键词
F-18flumazenil; PET; Bolus plus constant infusion; GABA shift;

机译：[F-18] Flumazenil;PET;推注加常数输注;GABA SHIFT;

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1. PET measurement of "GABA shift" in the rat brain: A preclinical application of bolus plus constant infusion paradigm of [F-18]flumazenil [J] . Kim Wook, Park Hyun Soo, Moon Byung Seok, Nuclear Medicine and Biology . 2017,第期

机译：宠物脑中“GABA换档”的宠物测量：推注Plus恒定输液范式的临床前应用[F-18]氟藏
2. Imaging of cerebral alpha(4)beta(2)* nicotinic acetylcholine receptors with (-)-[F-18]Flubatine PET: Implementation of bolus plus constant infusion and sensitivity to acetylcholine in human brain [J] . Hillmer A. T., Esterlis I., Gallezot J. D., NeuroImage . 2016,第Null期

机译：（-）-[F-18]氟丁胺PET对脑α（4）β（2）*烟碱型乙酰胆碱受体的成像：推注加恒定输注以及对人脑中乙酰胆碱的敏感性
3. GABA(A) receptor subtypes in the mouse brain: Regional mapping and diazepam receptor occupancy by in vivo [F-18]flumazenil PET [J] . Herde Adrienne Mueller, Benke Dietmar, Ralvenius William T., NeuroImage . 2017,第期

机译：GABA（a）小鼠脑中的受体亚型：在体内测绘和Diazepam受体占用患者[F-18] Flumazenil Pet
4. A Nonlinear Biphasic Model for Mass Transport During Constant Flow-Rate Infusion Into Brain Tissue [C] . Joshua H. Smith, José Jaime Garcia ASME summer bioengineering conference;SBC2010 . 2010

机译：恒流速率输注到脑组织过程中的质量传输的非线性双相模型。
5. The development of strategic characteristics in international corporate alliances: A study on paradigm shift of competitive strategy in the semiconductor industry. [D] . Uchida, Yasuro. 1998

机译：国际公司联盟战略特征的发展：半导体行业竞争战略范式转变的研究。
6. Test-Retest Reproducibility of 11C-(+)-PHNO PET Using the Bolus Plus Constant Infusion Paradigm [O] . Dianne E. Lee, Jean-Dominique Gallezot, Ming-Qiang Zheng, -1

机译：测试 - 重新测试11C - （+） - 使用推注加常数输注范式的Phno PET
7. Imaging of cerebral α4β2* nicotinic acetylcholine receptors with (−)-[18F]Flubatine PET: Implementation of bolus plus constant infusion and sensitivity to acetylcholine in human brain [O] . Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT, United States ( host institution ), Hillmer, A.T. ( author ), Esterlis, I. ( author ), 2016

机译：（-）-[18F]氟丁胺PET对脑α4β2*烟碱型乙酰胆碱受体的成像：推注加恒定输注以及对人脑中乙酰胆碱的敏感性

PET measurement of 'GABA shift' in the rat brain: A preclinical application of bolus plus constant infusion paradigm of [F-18]flumazenil

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