PET imaging of dopamine transporters with [F-18]FE-PE2I: Effects of anti-Parkinsonian drugs

Bang Ji-In; Jung In Soon; Song Yoo Sung; Park Hyun Soo; Moon Byung Seok; Lee Byung Chul; Kim Sang Eun

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PET imaging of dopamine transporters with [F-18]FE-PE2I: Effects of anti-Parkinsonian drugs

机译：用[F-18] Fe-PE2I的多巴胺转运蛋白的宠物成像：抗帕金森药的影响

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Purpose: This study aimed to assess the striatal [F-18]FE-PE2I binding and the immunohistochemical stain of tyrosine hydroxylase (TH) in the striatum, and to evaluate the effects of therapeutic drugs on [F-18]FE-PE2I binding.

机译：目的：本研究旨在评估纹状体中酪氨酸羟化酶（TH）的纹状体[F-18] Fe-PE2I结合和免疫组化染色，并评估治疗药物对[F-18] Fe-PE2I结合的影响。

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来源
《Nuclear Medicine and Biology》 |2016年第2期|共7页
作者
Bang Ji-In; Jung In Soon; Song Yoo Sung; Park Hyun Soo; Moon Byung Seok; Lee Byung Chul; Kim Sang Eun;
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作者单位

Seoul Natl Univ Bundang Hosp Coll Med Dept Nucl Med 300 Gumi Dong Songnam 463707 South Korea;

Seoul Natl Univ Bundang Hosp Coll Med Dept Nucl Med 300 Gumi Dong Songnam 463707 South Korea;

Seoul Natl Univ Bundang Hosp Coll Med Dept Nucl Med 300 Gumi Dong Songnam 463707 South Korea;

Seoul Natl Univ Bundang Hosp Coll Med Dept Nucl Med 300 Gumi Dong Songnam 463707 South Korea;

Seoul Natl Univ Bundang Hosp Coll Med Dept Nucl Med 300 Gumi Dong Songnam 463707 South Korea;

Seoul Natl Univ Bundang Hosp Coll Med Dept Nucl Med 300 Gumi Dong Songnam 463707 South Korea;

Seoul Natl Univ Bundang Hosp Coll Med Dept Nucl Med 300 Gumi Dong Songnam 463707 South Korea;

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原文格式 PDF
正文语种 eng
中图分类放射医学;
关键词
Parkinson's disease (PD); Dopamine transporter (DAT); (E)-N-(3-iodoprop-2-enyl)-2beta-carbofluoroethoxy-3beta-(4 '-methyl-phenyl) nortropane; Levodopa; Positron emission tomography (PET);

机译：帕金森病（PD）;多巴胺转运蛋白（DAT）;（e）-N-（3-碘丙醇-2-烯基）-2beta-碳氟乙氧基-3β-（4'-甲基 - 苯基）萘烷;左旋多巴;正电子发射断层扫描（宠物）;

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专利

1. PET imaging of dopamine transporters with [F-18]FE-PE2I: Effects of anti-Parkinsonian drugs [J] . Bang Ji-In, Jung In Soon, Song Yoo Sung, Nuclear Medicine and Biology . 2016,第2期

机译：[F-18] FE-PE2I对多巴胺转运蛋白的PET成像：抗帕金森病药物的作用
2. In Vitro Ligand Binding Kinetics Explains the Pharmacokinetics of [F-18]FE-PE2I in Dopamine Transporter PET Imaging [J] . Kukk Siim, Loog Olavi, Hiltunen Jukka-Veli, ACS medicinal chemistry letters . 2018,第12期

机译：体外配体结合动力学解释了在多巴胺转运仪PET成像中[F-18] Fe-PE2I的药代动力学
3. In Vitro Autoradiography and In Vivo Evaluation in Cynomolgus Monkey of [F-18]FE-PE2I, a New Dopamine Transporter PET Radioligand [J] . VarroneAndrea, SteigerCarsten, SchouMagnus, Synapse . 2009,第10期

机译：多巴胺转运蛋白PET放射性配体[F-18] FE-PE2I食蟹猴的体外放射自显影和体内评估。
4. Utilization of epitope-tagged knock-in mice for IP-MS/MS analysis of the effects of drug treatments on the dopamine transporter interactome [C] . Sarah Rogstad, John Caltagarone, Shiqi MaAlexander Sorkin, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2013

机译：利用表位标记的敲击小鼠的IP-MS / MS分析药物处理对多巴胺转运蛋白酶的影响
5. The short- and long-term effects of chronic late postnatal blockade of the dopamine transporter on cerebral glucose utilization and dopamine D(1)/D(2) receptors in the rat brain. [D] . Frick, Glen Steven. 1998

机译：慢性后期产后多巴胺转运蛋白对大鼠大脑中葡萄糖利用和多巴胺D（1）/ D（2）受体的慢性短期和长期影响。
6. Dopamine Transporter Imaging in Parkinson Disease: Progressive Changes and Therapeutic Modification after Anti-parkinsonian Medications [O] . Ken Ikeda, Junya Ebina, Kiyokazu Kawabe, 2019

机译：帕金森病中的多巴胺转运蛋白成像：抗帕金森病药物治疗后的逐步变化和治疗修饰
7. Dopamine Transporter Imaging in Parkinson Disease: Progressive Changes and Therapeutic Modification after Anti-parkinsonian Medications [O] . Ken Ikeda, Junya Ebina, Kiyokazu Kawabe, 2019

机译：在帕金森病中的多巴胺转运蛋白成像：抗帕金森治疗后的进步变化和治疗修饰

PET imaging of dopamine transporters with [F-18]FE-PE2I: Effects of anti-Parkinsonian drugs

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