Development of LiCl-containing calcium aluminate cement for bone repair and remodeling applications

摘要

The effect of LiCl additions on the in vitro bioactivity, hemolysis, cytotoxicity, compressive strength and setting time of calcium aluminate cements was studied. Calcium aluminate clinker (AC) was obtained via solid state reaction from reagent grade chemicals of CaCO3 and Al2O3. Calcium aluminate cements (CAC) were prepared by mixing the clinker with water or aqueous LiC1 solutions (0.01, 0.0125 or 0.015 M (M)) using a w/c ratio of OA. After 21 days of immersion in a simulated body fluid (SBF) at physiological conditions of temperature and pH, a Ca-P rich layer, identified as hydroxyapatite (HA), was formed on the cement without LiCI and on the cement prepared with 0.01 M of LiC1 solution. This indicates the high bioactivity of these cements. The cements setting times were significantly reduced using LiCl. The measured hemolysis percentages, all of them lower than 5%, indicated that the cements were not hemolytic The compressive strength of the cements was not negatively affected by the LiC1 additions. The obtained cement when a solution of LiC1 0.010 M was added, presented high compressive strength, appropriated bioactivity, no cytotoxicity and low setting time, making this material a potentially bone cement. (C) 2016 Elsevier B.V. All rights reserved.