Mimicking the Phenomenon of Ischemic Preconditioning by Actions on Cannabinoid Receptors: The Roles of Protein Kinase C and NO Synthase

摘要

Stimulation of CB1 receptors was found to mimic the phenomenon of preconditioning. As the cardioprotective effect of the cannabinoid HU-210 is seen in both in vivo experiments and in vitro studies, there are grounds for suggesting that the protective effects of HU-210 are mediated by activation of cardiac CB1 receptors. The cardioprotective effect of the cannabinoid HU-210 was found to be linked with stimulation of protein kinase C, while NO synthase has no role in the protective action of stimulation of CB1 receptors.