The Relationship between Mismatch Negativity and the COMT Val108/158Met Genotype in Schizophrenia

摘要

o -methyltransferase (COMT) is a key enzyme involved in regulating dopamine transmission within the prefrontal cortex. A preliminary study suggested that the COMT Val108/158Met genotype (rs4680) is related to cognitive function in schizophrenia. Both the COMT Val108/158Met genotype and MMN are related to cognitive function, but no studies have reported on the relationship between MMN and the COMTVal108/158Met genotype in schizophrenia. This study therefore examined the relationship between COMT Val108/158Met genotype and MMN. The duration of MMN was measured, and the COMT Val108/158Met polymorphism was detected by polymerase chain reaction-restriction fragment length polymorphism in 49 Japanese schizophrenia patients (Val/Val, n = 21; Met carriers, n = 28). Amplitude and latency of MMN were compared between Val/Val and Met carriers.