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The Potential Role of Gap Junctional Plasticity in the Regulation of State

机译:间隙连接可塑性在国家调节中的潜在作用

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摘要

Electrical synapses are the functional correlate of gap junctions and allow transmission of small molecules and electrical current between coupled neurons. Instead of static pores, electrical synapses are actually plastic, similar to chemical synapses. In the thalamocortical system, gap junctions couple inhibitory neurons that are similar in their biochemical profile, morphology, and electrophysiological properties. We postulate that electrical synaptic plasticity among inhibitory neurons directly interacts with the switching between different firing patterns in a state-dependent and type-dependent manner. In neuronal networks, electrical synapses may function as a modifiable resonance feedback system that enables stable oscillations. Furthermore, the plasticity of electrical synapses may play an important role in regulation of state, synchrony, and rhythmogenesis in the mammalian thalamocortical system, similar to chemical synaptic plasticity. Based on their plasticity, rich diversity, and specificity, electrical synapses are thus likely to participate in the control of consciousness and attention.
机译:电突触是间隙结的功能相关性,并且允许在偶联神经元之间传递小分子和电流。电气突触实际上是塑料,而是类似于化学突触的电气突触而不是静态毛孔。在Thalamocoric系统中,间隙交叉点在其生化型材,形态和电生理学性质中具有相似的抑制性神经元。我们假设抑制性神经元之间的电突触可塑性直接相互作用,以状态依赖性和类型依赖的方式在不同的烧制模式之间切换。在神经元网络中,电突触可以用作可修改的谐振反馈系统,其能够稳定振荡。此外,电突触的可塑性可能在哺乳动物炎症系统中的状态,同步和节律发生中起着重要作用,类似于化学突触塑性。根据他们的可塑性,丰富的多样性和特异性,电气突触可能会参与控制意识和注意力。

著录项

  • 来源
    《Neuron》 |2017年第6期|共21页
  • 作者单位

    Ctr Integrat Brain Res Seattle Childrens Res Inst Seattle WA 98101 USA;

    Ctr Integrat Brain Res Seattle Childrens Res Inst Seattle WA 98101 USA;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 神经病学;
  • 关键词

  • 入库时间 2022-08-20 04:35:28

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