Design and synthesis of new functionalized isoindigo and (3Z,3 ' Z)-3,3 '-(ethane-1,2-diylidene)bis(indolin-2-one) derivatives

摘要

A library of N,N-substituted isoindigo derivatives were prepared by reaction of isoindigo with a variety of alkylating agents in the presence of MeONa under mild conditions in yields of 65-80%. A new, more efficient synthesis of (3Z,3'Z)-3,3'-(ethane-1,2-diylidene)bis(indolin-2-one) is described by reaction of oxindole with glyoxal at reflux in methanol-a small library of N,N'-substituted derivatives were also prepared in 60-70% yield.