One-pot synthesis of 2,3-diphenyl-6,7-dihydroimidazo[1,2-f]phenanthridin-8(5H)-ones catalyzed by CuI/L-proline

摘要

2-(2-Bromophenyl)-4,5-diphenyl-1H-imidazole was used as an aryl halide to underwent alpha-arylation with 1,3-cyclohexanedione first, and then a nucleophilic addition and dehydration to give 2,3-diphenyl-6,7-dihydroimidazo[1,2-f]phenanthridin-8(5H)-one derivatives in good yields. This one-pot CuI-catalyzed procedure provided an efficient method for the synthesis of fused tetracyclic heterocycles containing both imidazole and phenanthridine moieties.