Isocyanide-based multicomponent reaction for the formation of 1,3-oxathiolane-2-imine derivatives

摘要

The adduct of isocyanide and elemental sulfur has been employed as the isothiocyanate source in reaction with oxirane to form 1,3-oxathiolane-2-imine derivatives. The optimum conditions are developed using HMPA at 55 degrees C for 12 h. Various isocyanides and oxiranes were tolerated under the optimum conditions.