Alzheimer's disease like pathology induced six weeks after aggregated amyloid-beta injection in rats: increased oxidative stress and impaired long-term memory with anxiety-like behavior

摘要

Objectives: Amyloid-beta (A beta) peptide deposition into insoluble plaques is a pathological hallmark of Alzheimer's disease (AD), but soluble oligomeric A beta is considered to be more potent and has been hypothesized to directly impair learning and memory. Also, evidences from some clinical studies indicated that A beta oligomer formation is the major cause for early AD onset. However, the biochemical mechanism involved in the oligomer-induced toxicity is not very well addressed. So, thise present study was undertaken to study the effects of single intracerebroventricular (icv) injection of protofibrillar A beta 1-42 on the behavioral and biochemical profile in rats.