A novel action of lacosamide on GABA(A) currents sets the ground for a synergic interaction with levetiracetam in treatment of epilepsy

摘要

Epilepsy is one of the most common chronic neurological diseases, and its pharmacological treatment holds great importance for both physicians and national authorities, especially considering the high proportion of drug resistant patients (about 30%). Lacosamide (LCM) is an effective and well-tolerated new -generation antiepileptic drug (AED), currently licensed as add-on therapy for partial-onset seizures. However, LCM mechanism of action is still a matter of debate, although its effect on the voltage sensitive sodium channels is by far the most recognized.