Isolation and identification of two new compounds from thePenicilliumsp. SYPF7381

摘要

Two new compounds, (7R,2E,5E)-3,5,7-trimethyl-2,5-octadienedioic-8-methyl ester (1) and neovasipyridone G (3), together with a new natural product compound (7R,2E,5E)-3,5,7-trimethyl-2,5-octadienedioic acid (2), and six known compounds (4-9) were isolated fromPenicilliumsp. SYPF7381. Their structures were elucidated on the basis of extensive spectroscopic analysis, and the absolute configurations of compounds1and2were determined by optical rotation. The absolute configuration of compound3was determined by means of electronic circular dichroism (ECD) calculation. In addition, thein vitroanti-inflammatory activities of all compounds were assayed in RAW 264.7 cells by assessing LPS-induced NO production. Furthermore, the structure-antiinflammation activity relationships for these isolated compounds were summarized based on the experimental as well as the docking results.