Comment on 'Should COVID-19 Concern Nephrologists? Why and to What Extent? The Emerging Impasse of Angiotensin Blockade'

摘要

Dear Editor, We read with great interest the review article by Perico et al. [1] "Should COVID-19 Concern Nephrologists? Why and to What Extent? The Emerging Impasse of Angiotensin Blockade." The authors hypothesized that angiotensin receptor antagonists (ARBs) can prevent the entry of the novel coronavirus into the cell by changing the structure of angiotensin-converting enzyme 2 (ACE2). In addition, they said that ARBs may protect against acute respiratory distress syndrome (ARDS) by increasing the angiotensin 1-7 level. We think ARBs may exacerbate the 2019 novel coronavirus disease (COVID-19) infection by increasing the ACE2 level. We would like to point out that ARBs should be discontinued in COVID-19 infection.