B‐type natriuretic peptide is a useful biomarker for the estimation of volume overload in children with hypertension on peritoneal dialysis

摘要

ABSTRACT Aim The aim of the present study was to evaluate the usefulness of serum B‐type natriuretic peptide (BNP) as a biomarker of fluid retention in hypertensive children on peritoneal dialysis (PD). Methods Hypertensive children on PD were included. The changes (?) of body weight (BWt), blood pressure (BP) and serum BNP at initial and follow‐up periods were reviewed. Data are presented as mean?±?standard deviation (median, minimum – maximum). Wilcoxon signed‐rank test was used to evaluate the changes in BWt, BP, and BNP. Linear regression analysis was applied for the correlation between the changes of BNP and BP. Results A total of 56 hypertensive events were evaluated in 30 patients. Initial findings were BWt 30.5?±?22.4 (26.5, 3.0–93.5) kg, systolic BP (SBP) 153.3?±?21.5 (150, 110–241) mmHg, diastolic BP (DBP) 100.1?±?22.3, (99.5, 49–181) mmHg, BNP 3579.3?±?6328.9 (1198.5, 305–22?028) pg/mL. Follow‐up results were BWt 29.1?±?21.3 (25.0, 3.12–86) kg, SBP 116.4?±?17.8 (117.5, 82–150) mmHg, DBP 73.3?±?14.2 (75.0, 42.0–101.0) mmHg, BNP 63.5?±?49.2 (60.5, 2–261) pg/mL. ?SBP (?23.1?±?13.8, ?22.8, ?46.9 ‐ 22.5%, P? 0.001), ?DBP (?24.1?±?19.2, ?24.7, ?55.6 – 23.2%, P? 0.001) and ?BNP (?93.5?±?8.1, ?96.7, ?99.9 – ‐61.0%, P? 0.001) dropped significantly after reduction of ?BWt (?4.8?±?4.7, ?4.8, ?18.7 – 5.6%, P? 0.001). The ?BNP were significantly correlated with ?SBP (adjusted R square?=?0.221, P? 0.001) and ?DBP (adjusted R square?=?0.203, P? 0.001). Conclusions Serum B‐type natriuretic peptide should be measured in hypertensive patients on PD to evaluate the volume status.