Rapid functionalization of multiple C-H bonds in unprotected alicyclic amines

摘要

The preparation of unprotected alicyclic amines containing variable substituents in multiple ring positions typically requires multistep synthetic sequences. Now, an advance in C-H bond functionalization methodology that enables the convenient preparation of elusive endocyclic 1-azaallyl anions allows the introduction of up to three substituents in a single operation.