Optical Blood Glucose Sensor Based on Multimode Interference (MMI) Fabricated by Thermal Imprint Process

摘要

Recently, optical passive devices and active devices have drawn considerable attention for several applications such as medicine, bio-technology and chemistry. High sensitive blood glucose sensor is important to many numbers of diabetic patients for detecting the glucose concentration of blood. Conventional blood glucose sensors mainly used electrochemical method to detect the blood glucose. However, electrochemical method has a limitation of resolution by using the enzyme. In this study, we proposed a polymeric blood glucose sensor for monitoring the blood glucose based on planar light wave circuit device to improve the sensitivity. We designed a simple Multimode interference (MMI) optical device occurring wavelength's shift due to changing the refractive index. The proposed sensor designed 1 by 2 MMI, which was fabricated by using imprint process. With applying temperature by 145 degrees C and 4 MPa pressure at PMMA sheet, 14 mu m of Multimode diameter, 6 mu m of single mode diameter and 6 mu m pattern depth were formed successfully. The resolution of proposed sensor is 0.18803 mg/100 ml by wavelength shift according to changing the refractive index of glucose concentration and the accuracy of sensor is within 1%.