New Acetylated Terpenoids from Sponge Rhabdastrella providentiae Inhibit NO Production in LPS Stimulated BV2 Cells

摘要

Three new acetylated terpenoids, rhabdaprovidines A-C (1-3), were isolated from the Vietnamese sponge Rhabdastrella providentiae. Their chemical structures were established by BR-ESL-MS, 1D and 2D-NMR experiments. These compounds share 6,6,5-tricyclic nucleus of isomalabaricane-type triterpene, the specific secondary constituents from Rhabdastrella species. Compounds 1-3 inhibited NO production in LPS stimulated BV2 cells with IC50 values of 20.4 +/- 1.5, 17.5 +/- 0.9, and 46.8 +/- 2.3 mu M, respectively.