Effect of botulinum toxin type A on the capsule around a subpectoral implant for breast augmentation.

摘要

The formation of a fibrous capsule around a silicone breast implant is part of a physiologic foreign body reaction after breast augmentation. In contrast, the formation of capsular contracture is a local complication of unknown cause. The current treatments focus on resection of the contractive capsule using surgical procedures but these methods cannot obtain excellent therapeutic results. Recurrence of capsular contracture is a very common problem. Treatment of cap--sular contracture has progressed very little and understanding of the underlying causes remains poor. The authors believe that excellent control of capsular contracture depends on full comprehension of the molecular processes involved. A better understanding of the pathophysiology of capsular contracture plays an important role in developing novel therapeutical strategies.