Phenolic Components from the Aerial Parts of Agrimonia pilosa

摘要

Two new resorcinol derivatives, named agrimopilosides A and B (1 and 2), along with two known compounds, (2S, 3S)-aromadendrin 3-O-beta-D-glucopyranoside (3), (2S, 3S)-glucodistylin (4) were isolated from the aerial parts of Agrimonia pilosa. Their chemical structures were determined by mean of HRMS, NMR, CD spectra, and as well as by comparison with the reported data. At concentration of 20 mu M, compounds 1-4 modestly inhibited NO production in LPS-stimulated RAW264.7 cells, with the inhibitory rates in the range of 9.55-33.73%. None of them showed cytotoxicity toward HepG2, MCF-7, and SK-LU-1 human cancer cells by MTT assay.