Antiangiogenic Chromanones from Cynanchum thesiodes

摘要

A total of 10 chromanone derivatives (1-10), including two new compounds (1 and 2), were isolated from the fruits of Cynanchum thesiodes, and their structures were identified based on UV, IR, MS and NMR spectroscopic data, and comparison with those of reference compounds. The isolated compounds (1-10) were evaluated for their antiangiogenic activity by MTT assay using axitinib as a positive control. As a result, 1, 2, 3 and 9 exhibited important antiangiogenic activity with IC50 values of 13.8, 11.9, 43.6, and 74.8 mu M, respectively.