Crohn's and Parkinson disease: is LRRK2 lurking around the corner?

摘要

Exome sequencing of patients with Crohn's disease (CD) of Ashkenazi Jewish descent and genotyping of large case-control cohorts has identified new CD risk and protective variants of LRRK2, the most common genetic determinant of Parkinson disease. These findings provide new insights into the pathophysiology of these two seemingly unrelated disorders.