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A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome

机译:阿尔茨海默病的遗传原因:唐氏综合征的机械洞察

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Down syndrome, which arises in individuals carrying an extra copy of chromosome 21, is associated with a greatly increased risk of early-onset Alzheimer disease. It is thought that this risk is conferred by the presence of three copies of the gene encoding amyloid precursor protein (APP)-an Alzheimer disease risk factor-although the possession of extra copies of other chromosome 21 genes may also play a part. Further study of the mechanisms underlying the development of Alzheimer disease in people with Down syndrome could provide insights into the mechanisms that cause dementia in the general population.
机译:唐氏综合症,其出现在携带额外染色体21级染色体拷贝的个体中,与早期发病的阿尔茨海默病的风险大有关。 据认为,这种风险是通过编码淀粉样蛋白前体蛋白(APP)的基因的三个副本赋予这种风险 - Alzheimer疾病风险因子 - 虽然拥有其他染色体21个基因的额外拷贝也可能发挥作用。 进一步研究患有唐氏综合症人们的阿尔茨海默病发展的机制可以提供对导致一般人群痴呆症的机制的见解。

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