Neural Development: No entry for AnkG.

摘要

The scaffolding protein ankyrin C (AnkG; also known as ANK3) is restricted to the proximal part of axons, where it is required for the assembly of the axon initial segment (AIS) and for maintaining neuronal polarity. How this precise localization is controlled was not known, but now, Rasband and colleagues show that a cytoskeleton in the distal part of the axon forms a boundary that spatially restricts AnkC clustering and thereby AIS assembly.