Synaptic plasticity: ARC plays inverse tag at synapses.

摘要

Activity-regulated transcription of the immediate early gene Arc is followed by targeting of ARC protein to the synapse, where (in addition to other effects) it is thought to weaken synaptic strength by promoting the endocytosis of AMPA receptors (AMPARs). However, the mechanisms by which ARC targets particular synapses are unknown. Okuno et al. now show that ARC localizes to synapses that exhibit reduced activity by interacting with an inactive form of Ca~(2+)/calmodulin-dependent protein kinase IIbeta (CaMKlIbeta).