Neurodegenerative disease: Dishing up Alzheimer's disease.

摘要

Necroptosis (also known as programmed necrosis) occurs following the activation of receptor-interacting protein 1 (RIP1; also known as RIPK1) jp response to the ligation of tumour necrosis factor receptor (TNFR) and the formation of a RIP1-RIP3 complex (necrosome). However, the events that mediate necroptosis downstream of necrosome formation remain largely elusive. Two recent studies by Wang and colleagues delineate the effectors of the necroptotic cell death pathway downstream of RIP3 activation.