NFI transcription factors provide chromatin access to maintain stem cell identity while preventing unintended lineage fate choices

Adam Rene C.; Yang Hanseul; Ge Yejing; Infarinato Nicole R.; Gur-Cohen Shiri; Miao Yuxuan; Wang Ping; Zhao Yilin; Lu Catherine P.; Kim Jeong E.; Ko Joo Y.; Paik Seung S.; Gronostajski Richard M.; Kim Jaehwan; Krueger James G.; Zheng Deyou; Fuchs Elaine

首页> 外文期刊>Nature cell biology >NFI transcription factors provide chromatin access to maintain stem cell identity while preventing unintended lineage fate choices

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NFI transcription factors provide chromatin access to maintain stem cell identity while preventing unintended lineage fate choices

机译：NFI转录因子提供染色质进入，以维持干细胞标识，同时防止意外的谱系命运选择

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Adam, Yang et al. show that the transcription factors NFIB and NFIX promote stemness by establishing chromatin accessibility and regulating the super-enhancers that govern bulge stem cell identity.

机译：亚当，杨等人。表明转录因子NFIB和NFIX通过建立染色质可用性和调节治理凸起干细胞标识的超强增强剂来促进茎。

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《Nature cell biology》 |2020年第6期|共27页
作者
Adam Rene C.; Yang Hanseul; Ge Yejing; Infarinato Nicole R.; Gur-Cohen Shiri; Miao Yuxuan; Wang Ping; Zhao Yilin; Lu Catherine P.; Kim Jeong E.; Ko Joo Y.; Paik Seung S.; Gronostajski Richard M.; Kim Jaehwan; Krueger James G.; Zheng Deyou; Fuchs Elaine;
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作者单位

Rockefeller Univ Howard Hughes Med Inst Robin Chemers Neustein Lab Mammalian Cell Biol &

1230;

Rockefeller Univ Howard Hughes Med Inst Robin Chemers Neustein Lab Mammalian Cell Biol &

1230;

Rockefeller Univ Howard Hughes Med Inst Robin Chemers Neustein Lab Mammalian Cell Biol &

1230;

Rockefeller Univ Howard Hughes Med Inst Robin Chemers Neustein Lab Mammalian Cell Biol &

1230;

Rockefeller Univ Howard Hughes Med Inst Robin Chemers Neustein Lab Mammalian Cell Biol &

1230;

Rockefeller Univ Howard Hughes Med Inst Robin Chemers Neustein Lab Mammalian Cell Biol &

1230;

Albert Einstein Coll Med Dept Genet New York NY USA;

Albert Einstein Coll Med Dept Genet New York NY USA;

Rockefeller Univ Howard Hughes Med Inst Robin Chemers Neustein Lab Mammalian Cell Biol &

1230;

Hanyang Univ Coll Med Dept Dermatol Seoul South Korea;

Hanyang Univ Coll Med Dept Dermatol Seoul South Korea;

Hanyang Univ Coll Med Dept Pathol Seoul South Korea;

SUNY Buffalo Dept Biochem Dev Genom Grp NYS Ctr Excellence Bioinformat &

Life Sci New York NY;

Rockefeller Univ Lab Invest Dermatol 1230 York Ave New York NY 10021 USA;

Rockefeller Univ Lab Invest Dermatol 1230 York Ave New York NY 10021 USA;

Albert Einstein Coll Med Dept Genet New York NY USA;

Rockefeller Univ Howard Hughes Med Inst Robin Chemers Neustein Lab Mammalian Cell Biol &

1230;

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正文语种 eng
中图分类细胞生物学;
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专利

1. NFI transcription factors provide chromatin access to maintain stem cell identity while preventing unintended lineage fate choices [J] . Adam Rene C., Yang Hanseul, Ge Yejing, Nature cell biology . 2020,第6期

机译：NFI转录因子提供染色质进入，以维持干细胞标识，同时防止意外的谱系命运选择
2. Factors Released from Endothelial Cells Exposed to Flow Impact Adhesion, Proliferation, and Fate Choice in the Adult Neural Stem Cell Lineage [J] . Dumont Courtney M., Piselli Jennifer M., Kazi Nadeem, Stem cells and development . 2017,第16期

机译：从内皮细胞释放的因素暴露于成年神经干细胞谱系中的流动冲击粘附，增殖和命运选择
3. Geminin promotes neural fate acquisition of embryonic stem cells by maintaining chromatin in an accessible and hyperacetylated state [J] . Dhananjay Yellajoshyula, Ethan S. Patterson, Matthew S. Elitt, Proceedings of the National Academy of Sciences of the United States of America . 2011,第8期

机译：Geminin通过将染色质维持在可进入的和高度乙酰化的状态来促进胚胎干细胞的神经命运获取
4. Computer and Statistical Analysis of Transcription Factor Binding and Chromatin Modifications by ChlP-seq Data in Embryonic Stem Cell [C] . Yuriy Orlov, Nina Orlova, Mikael Huss, International symposium on integrative bioinformatics, 8th annual meeting . 2012

机译：胚胎干细胞中ChlP-seq数据的转录因子结合和染色质修饰的计算机和统计分析
5. Chromatin-modifying factor Mll1 maintains neural stem cell regional identity in the postnatal mouse brain [D] . Delgado, Ryan N. 2015

机译：染色质修饰因子Mll1维持出生后小鼠大脑中的神经干细胞区域身份
6. Geminin promotes neural fate acquisition of embryonic stem cells by maintaining chromatin in an accessible and hyperacetylated state [O] . Dhananjay Yellajoshyula, Ethan S. Patterson, Matthew S. Elitt, 2011

机译：Geminin通过将染色质维持在可进入的和高度乙酰化的状态来促进胚胎干细胞的神经命运获取
7. Conserved Transcription Factors Control Chromatin Accessibility and Gene Expression to Maintain Cell Fate Stability and Restrict Reprogramming of Differentiated Cells [O] . Maria A. Missinato, Sean A. Murphy, Michaela Lynott, 2021

机译：保守转录因子控制染色质可用性和基因表达，以维持细胞命运稳定性并限制分化细胞的重新编程

NFI transcription factors provide chromatin access to maintain stem cell identity while preventing unintended lineage fate choices

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