COVID-19 severity correlates with airway epithelium-immune cell interactions identified by single-cell analysis

Chua Robert Lorenz; Lukassen Soeren; Trump Saskia; Hennig Bianca P.; Wendisch Daniel; Pott Fabian; Debnath Olivia; Thuermann Loreen; Kurth Florian; Voelker Maria Theresa; Kazmierski Julia; Timmermann Bernd; Twardziok Sven; Schneider Stefan; Machleidt Felix; Mueller-Redetzky Holger; Maier Melanie; Krannich Alexander; Schmidt Sein; Balzer Felix; Liebig Johannes; Loske Jennifer; Suttorp Norbert; Eils Juergen; Ishaque Naveed; Liebert Uwe Gerd; von Kalle Christof; Hocke Andreas; Witzenrath Martin; Goffinet Christine; Drosten Christian; Laudi Sven; Lehmann Irina; Conrad Christian; Sander Leif-Erik; Eils Roland

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COVID-19 severity correlates with airway epithelium-immune cell interactions identified by single-cell analysis

机译：Covid-19严重程度与通过单细胞分析鉴定的气道上皮细胞相互作用相关

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Single-cell analysis of COVID-19 patient samples identifies activated immune pathways that correlate with severe disease.

机译：Covid-19患者样品的单细胞分析鉴定了与严重疾病相关的活化免疫途径。

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《Nature biotechnology》 |2020年第8期|共22页
作者
Chua Robert Lorenz; Lukassen Soeren; Trump Saskia; Hennig Bianca P.; Wendisch Daniel; Pott Fabian; Debnath Olivia; Thuermann Loreen; Kurth Florian; Voelker Maria Theresa; Kazmierski Julia; Timmermann Bernd; Twardziok Sven; Schneider Stefan; Machleidt Felix; Mueller-Redetzky Holger; Maier Melanie; Krannich Alexander; Schmidt Sein; Balzer Felix; Liebig Johannes; Loske Jennifer; Suttorp Norbert; Eils Juergen; Ishaque Naveed; Liebert Uwe Gerd; von Kalle Christof; Hocke Andreas; Witzenrath Martin; Goffinet Christine; Drosten Christian; Laudi Sven; Lehmann Irina; Conrad Christian; Sander Leif-Erik; Eils Roland;
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Berlin Inst Hlth BIH Ctr Digital Hlth Berlin Germany;

Berlin Inst Hlth BIH Ctr Digital Hlth Berlin Germany;

Free Univ Berlin Berlin Germany;

Berlin Inst Hlth BIH Ctr Digital Hlth Berlin Germany;

Free Univ Berlin Berlin Germany;

Free Univ Berlin Berlin Germany;

Berlin Inst Hlth BIH Ctr Digital Hlth Berlin Germany;

Free Univ Berlin Berlin Germany;

Free Univ Berlin Berlin Germany;

Univ Hosp Leipzig Dept Anesthesiol &

Intens Care Leipzig Germany;

Free Univ Berlin Berlin Germany;

Max Planck Inst Mol Genet Sequencing Core Facil Berlin Germany;

Berlin Inst Hlth BIH Ctr Digital Hlth Berlin Germany;

Berlin Inst Hlth BIH Ctr Digital Hlth Berlin Germany;

Free Univ Berlin Berlin Germany;

Free Univ Berlin Berlin Germany;

Univ Hosp Leipzig Inst Virol Leipzig Germany;

Free Univ Berlin Berlin Germany;

Free Univ Berlin Berlin Germany;

Free Univ Berlin Berlin Germany;

Berlin Inst Hlth BIH Ctr Digital Hlth Berlin Germany;

Free Univ Berlin Berlin Germany;

Free Univ Berlin Berlin Germany;

Berlin Inst Hlth BIH Ctr Digital Hlth Berlin Germany;

Berlin Inst Hlth BIH Ctr Digital Hlth Berlin Germany;

Univ Hosp Leipzig Inst Virol Leipzig Germany;

Free Univ Berlin Berlin Germany;

Free Univ Berlin Berlin Germany;

Free Univ Berlin Berlin Germany;

Free Univ Berlin Berlin Germany;

Free Univ Berlin Berlin Germany;

Univ Hosp Leipzig Dept Anesthesiol &

Intens Care Leipzig Germany;

Free Univ Berlin Berlin Germany;

Berlin Inst Hlth BIH Ctr Digital Hlth Berlin Germany;

Free Univ Berlin Berlin Germany;

Berlin Inst Hlth BIH Ctr Digital Hlth Berlin Germany;

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正文语种 eng
中图分类普通生物学;
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1. COVID-19 severity correlates with airway epithelium-immune cell interactions identified by single-cell analysis [J] . Chua Robert Lorenz, Lukassen Soeren, Trump Saskia, Nature biotechnology . 2020,第8期

机译：Covid-19严重程度与通过单细胞分析鉴定的气道上皮细胞相互作用相关
2. Airway mast cells and eosinophils correlate with clinical severity and airway hyperresponsiveness in corticosteroid-treated asthma. [J] . Gibson PG, Saltos N, Borgas T The Journal of Allergy and Clinical Immunology . 2000,第4期

机译：在皮质类固醇治疗的哮喘中，气道肥大细胞和嗜酸性粒细胞与临床严重程度和气道高反应性相关。
3. PAX7 target gene repression is a superior FSHD biomarker than DUX4 target gene activation, associating with pathological severity and identifying FSHD at the single-cell level [J] . Banerji Christopher R. S., Zammit Peter S. Human Molecular Genetics . 2019,第13期

机译：PAX7靶基因抑制是一种优异的FSHD生物标志物，比DUX4靶基因激活，与病理严重程度相关联，并在单细胞水平处识别FSHD
4. Identifying Statistically Significant Frequent Single-cell Inter-chromosomal Interactions with Networks [C] . Chanaka Bulathsinghalage, Lu Liu Annual midwest instruction and computing symposium . 2019

机译：识别具有网络统计意义的频繁单细胞染色体间相互作用
5. Single-cell Mechanics Provides a Sensitive, Quantitative, and Cell Geometry Independent Means for Investigating Protein and Nanoparticle-cell Interactions [D] . Zimmer, Christopher Charles 2011

机译：单细胞力学为研究蛋白质和纳米颗粒与细胞之间的相互作用提供了灵敏，定量和细胞几何独立的方法
6. Single-cell longitudinal analysis of SARS-CoV-2 infection in human airway epithelium identifies target cells alterations in gene expression and cell state changes [O] . Neal G. Ravindra, Mia Madel Alfajaro, Victor Gasque, 2021

机译：人体气道上皮中SARS-COV-2感染的单细胞纵向分析鉴定了靶细胞基因表达的改变和细胞状态变化
7. Single-cell longitudinal analysis of SARS-CoV-2 infection in human airway epithelium identifies target cells, alterations in gene expression, and cell state changes [O] . Neal G. Ravindra, Mia Madel Alfajaro, Victor Gasque, 2021

机译：人体气道上皮中SARS-COV-2感染的单细胞纵向分析鉴定了靶细胞，基因表达的改变和细胞状态变化

COVID-19 severity correlates with airway epithelium-immune cell interactions identified by single-cell analysis

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