Exploiting the apicoplast: apicoplast-targeting drugs and malaria vaccine development

摘要

The apicoplast, a relic plastid found in most Apicomplexan parasites, is a notable drug target. Certain antibiotics elicit a delayed death phenotype by targeting this organelle. Here, we review apicoplast-targeting drugs and their targets, particularly those that cause delayed death, and highlight its potential uses in malaria vaccine development. (C) 2017 Published by Elsevier Masson SAS on behalf of Institut Pasteur.