PIP-ing Lipids on Membranes: PTEN Takes the Cake

摘要

In this issue of Molecular Cell , describe a novel HPLC-MS method permitting separation of PI(3,4)P 2 and PI(4,5)P 2 , a technical issue hindering the phosphoinositide signaling field. They use this method to uncover a new target and critical role for PTEN in cancer. In this issue of Molecular Cell , Malek et?al. (2017) describe a novel HPLC-MS method permitting separation of PI(3,4)P 2 and PI(4,5)P 2 , a technical issue hindering the phosphoinositide signaling field. They use this method to uncover a new target and critical role for PTEN in cancer.