Hypermethylation of MIR21 in CD4+T cells from patients with relapsing-remitting multiple sclerosis associates with lower miRNA-21 levels and concomitant up-regulation of its target genes

Ruhrmann Sabrina; Ewing Ewoud; Piket Eliane; Kular Lara; Lorenzi Julio Cesar Cetrulo; Fernandes Sunjay Jude; Morikawa Hiromasa; Aeinehband Shahin; Sayols-Baixeras Sergi; Aslibekyan Stella; Absher Devin M.; Arnett Donna K.; Tegner Jesper; Gomez-Cabrero David; Piehl Fredrik; Jagodic Maja

首页> 外文期刊>Multiple sclerosis: clinical and laboratory research >Hypermethylation of MIR21 in CD4+T cells from patients with relapsing-remitting multiple sclerosis associates with lower miRNA-21 levels and concomitant up-regulation of its target genes

【24h】

Hypermethylation of MIR21 in CD4+T cells from patients with relapsing-remitting multiple sclerosis associates with lower miRNA-21 levels and concomitant up-regulation of its target genes

机译：复发患者CD4 + T细胞中的MiR21的高甲基化患者，延长MiRNA-21水平，伴随其靶基因的上调

获取原文

获取原文并翻译 | 示例

获取外文期刊封面目录资料

开具论文收录证明 >>

文献代查 >>

文献数据库（团队版） >>

页面导航

摘要
著录项
引文网络
相似文献
相关主题

摘要

Background: Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system caused by genetic and environmental factors. DNA methylation, an epigenetic mechanism that controls genome activity, may provide a link between genetic and environmental risk factors.

机译：背景：多发性硬化症（MS）是由遗传和环境因素引起的中枢神经系统的慢性炎症疾病。 DNA甲基化，一种控制基因组活动的表观遗传机制，可以提供遗传和环境风险因素之间的联系。

著录项

来源
《Multiple sclerosis: clinical and laboratory research》 |2018年第10期|共13页
作者
Ruhrmann Sabrina; Ewing Ewoud; Piket Eliane; Kular Lara; Lorenzi Julio Cesar Cetrulo; Fernandes Sunjay Jude; Morikawa Hiromasa; Aeinehband Shahin; Sayols-Baixeras Sergi; Aslibekyan Stella; Absher Devin M.; Arnett Donna K.; Tegner Jesper; Gomez-Cabrero David; Piehl Fredrik; Jagodic Maja;
展开▼
作者单位

Karolinska Inst Dept Clin Neurosci Ctr Mol Med L8-04 Karolinska Univ Hosp S-17176 Stockholm;

Karolinska Inst Dept Clin Neurosci Ctr Mol Med L8-04 Karolinska Univ Hosp S-17176 Stockholm;

Karolinska Inst Dept Clin Neurosci Ctr Mol Med L8-04 Karolinska Univ Hosp S-17176 Stockholm;

Karolinska Inst Dept Clin Neurosci Ctr Mol Med L8-04 Karolinska Univ Hosp S-17176 Stockholm;

Karolinska Inst Dept Clin Neurosci Ctr Mol Med L8-04 Karolinska Univ Hosp S-17176 Stockholm;

Dept Med Unit Computat Med Solna Sweden;

Dept Med Unit Computat Med Solna Sweden;

Karolinska Inst Dept Clin Neurosci Ctr Mol Med L8-04 Karolinska Univ Hosp S-17176 Stockholm;

Univ Pompeu Fabra UPF Barcelona Spain;

Inst Hosp Mar Invest Med IMIM Cardiovasc Epidemiol &

Genet Grp Barcelona Spain;

HudsonAlpha Inst Biotechnol Huntsville AL USA;

Univ Kentucky Coll Publ Hlth Lexington KY USA;

Dept Med Unit Computat Med Solna Sweden;

Dept Med Unit Computat Med Solna Sweden;

Karolinska Inst Dept Clin Neurosci Ctr Mol Med L8-04 Karolinska Univ Hosp S-17176 Stockholm;

Karolinska Inst Dept Clin Neurosci Ctr Mol Med L8-04 Karolinska Univ Hosp S-17176 Stockholm;

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类神经病学与精神病学;
关键词
CD4+T cells; autoimmunity; epigenetics; DNA methylation; microRNAs; multiple sclerosis; relapsing-remitting; miR-21;

机译：CD4 + T细胞;自身免疫;表观生物学;DNA甲基化;microRNA;多发性硬化;复发延续;MIR-21;

相似文献

外文文献
中文文献
专利

1. Hypermethylation of MIR21 in CD4+T cells from patients with relapsing-remitting multiple sclerosis associates with lower miRNA-21 levels and concomitant up-regulation of its target genes [J] . Ruhrmann Sabrina, Ewing Ewoud, Piket Eliane, Multiple sclerosis: clinical and laboratory research . 2018,第10期

机译：复发患者CD4 + T细胞中的MiR21的高甲基化患者，延长MiRNA-21水平，伴随其靶基因的上调
2. Comparison of Expression Levels of miR-29b-3p and miR-326 in T Helper-1 and T Helper-17 Cells Isolated from Responsive and Non-responsive Relapsing-remitting Multiple Sclerosis Patients Treated with Interferon-beta [J] . Leila Karimi, Nahid Eskandari, Vahid Shaygannejad, Iranian Journal Of Allergy, Asthma and Immunology . 2020,第4期

机译：与干扰素 - β对响应性和非响应复发复杂多发性硬化症患者的响应性和非响应复发患者分离的辅助-1和T辅助-17细胞表达水平的比较
3. Retinoic acid enhances the levels of IL-10 in TLR-stimulated B cells from patients with relapsing-remitting multiple sclerosis [J] . Eriksen Agnete Bratsberg, Berge Tone, Gustavsen Marte Wendel, Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology . 2015,第Null期

机译：视黄酸可提高复发缓解型多发性硬化症患者TLR刺激的B细胞中IL-10的水平
4. The Promoter Hypermethylation of DAPK Gene and p16 Gene in Non-Small Cell Lung Cancer Patients [C] . Zheng Shi-ying, Jiang Dong, Ge Jin-feng International Conference on Biomedical Engineering and Informatics;BMEI '09 . 2009

机译：非小细胞肺癌患者DAPK基因和p16基因的启动子甲基化
5. An investigation of early relapsing-remitting multiple sclerosis patients using diffusion tensor imaging and spectroscopy. [D] . Zaini, Wan Hazlin. 2013

机译：使用扩散张量成像和光谱法对早期复发缓解型多发性硬化症患者进行调查。
6. Hypermethylation of MIR21 in CD4+ T cells frompatients with relapsing-remitting multiple sclerosis associates with lowermiRNA-21 levels and concomitant up-regulation of its targetgenes [O] . Sabrina Ruhrmann, Ewoud Ewing, Eliane Piket, -1

机译：CD4 + T细胞中MIR21的超甲基化复发缓解型多发性硬化症患者伴有较低的miRNA-21水平及其靶标的伴随上调基因
7. Hypermethylation of MIR21 in CD4+ T cells from patients with relapsing-remitting multiple sclerosis associates with lower miRNA-21 levels and concomitant up-regulation of its target genes [O] . Ruhrmann Sabrina, Ewing Ewoud, Piket Eliane, 2017

机译：复发缓解型多发性硬化症患者的CD4 + T细胞中MIR21的超甲基化与较低的miRNA-21水平和其靶基因的上调相关

Hypermethylation of MIR21 in CD4+T cells from patients with relapsing-remitting multiple sclerosis associates with lower miRNA-21 levels and concomitant up-regulation of its target genes

摘要

著录项

引文网络

相似文献

相关主题

期刊订阅