The majority of natalizumab-treated MS patients have high natalizumab concentrations at time of re-dosing

van Kempen Zoe L. E.; Leurs Cyra E.; Witte Birgit I.; de Vries Annick; Wattjes Mike P.; Rispens Theo; Killestein Joep

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The majority of natalizumab-treated MS patients have high natalizumab concentrations at time of re-dosing

机译：大多数Natalizumab治疗的MS患者在重新定量时具有高幼稚的浓度

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Background: Natalizumab is efficacious in the treatment of relapsing-remitting multiple sclerosis. All patients receive the same treatment regimen of 300mg every 4weeks, despite differences in pharmacokinetics between individual patients.

机译：背景：Natalizumab在治疗复发延迟多发性硬化症时是有效的。尽管个体患者的药代动力学差异，所有患者均得到相同的治疗方案300mg。

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来源
《Multiple sclerosis: clinical and laboratory research》 |2018年第6期|共6页
作者
van Kempen Zoe L. E.; Leurs Cyra E.; Witte Birgit I.; de Vries Annick; Wattjes Mike P.; Rispens Theo; Killestein Joep;
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作者单位

Vrije Univ Amsterdam Med Ctr VUmc MS Ctr Amsterdam Amsterdam Neurosci Dept Neurol De Boelelaan;

Vrije Univ Amsterdam Med Ctr VUmc MS Ctr Amsterdam Amsterdam Neurosci Dept Neurol De Boelelaan;

Vrije Univ Amsterdam Med Ctr Dept Epidemiol &

Biostat Amsterdam Netherlands;

Sanquin Sanquin Diagnost Serv Biol Lab Amsterdam Netherlands;

Vrije Univ Amsterdam Med Ctr VUmc MS Ctr Amsterdam Amsterdam Neurosci Dept Radiol &

Nucl Med;

Sanquin Res &

Landsteiner Lab Dept Immunol Amsterdam Netherlands;

Vrije Univ Amsterdam Med Ctr VUmc MS Ctr Amsterdam Amsterdam Neurosci Dept Neurol De Boelelaan;

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原文格式 PDF
正文语种 eng
中图分类神经病学与精神病学;
关键词
Multiple sclerosis; natalizumab; concentration;

机译：多发性硬化;Natalizumab;浓度;

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专利

1. Response to "Letter to the editor on the paper: The majority of natalizumab-treated MS patients have high natalizumab concentrations at time of re-dosing" [J] . van Kempen Zoe L. E., Rispens Theo, Killestein Joep Multiple sclerosis: clinical and laboratory research . 2018,第6期

机译：回应“论文中的编辑函：大多数Natalizumab治疗的MS患者在重新定量时具有高幼稚素浓度”
2. The majority of natalizumab-treated MS patients have high natalizumab concentrations at time of re-dosing [J] . van Kempen Zoe L. E., Leurs Cyra E., Witte Birgit I., Multiple sclerosis: clinical and laboratory research . 2018,第6期

机译：大多数Natalizumab治疗的MS患者在重新定量时具有高幼稚的浓度
3. The majority of natalizumab-treated MS patients have high natalizumab concentrations at time of re-dosing [J] . van Kempen Zoe L. E., Leurs Cyra E., Witte Birgit I., Multiple sclerosis: clinical and laboratory research . 2018,第6期

机译：大多数Natalizumab治疗的MS患者在重新定量时具有高幼稚的浓度
4. Area under the concentrations versus time curve (AUC) based busulfan exposure monitoring in paediatric patients [C] . Tesfaye H., Klapkova E., Prusa R. European Association for Clinical Pharmacology and Therapeutics . 2009

机译：浓度下的面积与时间曲线（AUC）基于小儿患者的Busulfan暴露监测
5. Determination of the Levels and Concentrations of the Most Used Autism Spectrum Disorder Medications (Olanzapine, Risperidone and Quetiapine) in Autistic Patient’s Plasma by Using Lc/Ms/Ms [D] . Fraih, Dana Fayez. 2020

机译：通过使用LC / MS / MS测定自闭症患者血浆中最常用的自闭症谱系药物（Olanzapine，Risperidone和Quetiapine）的水平和浓度
6. Response to Letter to the editor on the paper: The majority of natalizumab-treated MS patients have high natalizumab concentrations at time of re-dosing [O] . Zoé LE van Kempen, Theo Rispens, Joep Killestein -1

机译：对给纸上编辑的信：大多数接受那他珠单抗治疗的MS患者在重新给药时那他珠单抗浓度很高的答复
7. Brainstem PML lesion mimicking\ud MS plaque in a natalizumab-treated MS patient. [O] . Tortorella C, Direnzo V, D'Onghia M, 2013

机译：模拟的脑干PML病变\ ud 那他珠单抗治疗的MS患者的MS斑块。

The majority of natalizumab-treated MS patients have high natalizumab concentrations at time of re-dosing

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